Courtney Southwick October 17, 2023 A process your body uses to stay warm in cool weather could one day lead to new therapies for obesity. Scientists have, for the first time, mapped the precise nerve pathways that activate brown fat, or brown adipose tissue (BAT), a specialized fat that generates heat. Low temperatures kick brown fat into...
Category: <span>Metabolic</span>
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Researchers uncover mechanism that may explain why some people can’t stop binging on unhealthy foods
by Buck Institute for Research on Aging Credit: CC0 Public DomainPeople overeat and become overweight for a variety of reasons. The fact that flavorful high-calorie food is often available nearly everywhere at any time doesn’t help. Buck researchers have determined for the first time why certain chemicals in cooked or processed foods, called advanced glycation...
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Tirzepatide Weight Loss Continues up to 1 Year
Miriam E. Tucker October 06, 2023 HAMBURG, Germany — The “twincretin” tirzepatide (Mounjaro) kept on producing “highly significant weight loss” when the drug was continued in a 1-year follow-up trial, and those who discontinued the drug regained some weight but not all. In Eli Lilly’s SURMOUNT-4 trial of 783 adults with obesity or overweight but not diabetes...
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Study shows medial preoptic area mediates depressive-like behaviors associated with ovarian hormone fluctuations
by Ingrid Fadelli , Medical Xpress The medial preoptic area mediates depressive-like behaviors associated with ovarian hormone fluctuations Electrophysiological recording from MPOA GABAergic neurons (Vgat+) demonstrated that these neurons reduced their spiking activity in HW-treated mice compared to non-HW controls (NHW). Credit to Can Tao.Fluctuations in the hormones secreted by women’s ovaries, namely estrogen and...
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Positive metabolic effects of gastric bypass found to disappear quickly
by Lund University PCA score plots for lipidomics data acquired in positive (ESI+; 80 annotated lipids) and negative (ESI-; 46 annotated lipids) ESI mode. PCA was conducted on (A,B) metabolite levels and (C,D) changes in metabolite levels (effects) within defined time ranges: short term (2 months vs. baseline), long term (12 vs. 2 months), cumulative (12 months vs. baseline),...
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Study identifies new drug target for preventing fatty liver disease
by eLife Credit: Pixabay/CC0 Public Domain Scientists have found a potential new drug target for untreatable fatty liver disease in humans, according to a study published today in eLife. Their findings, from mice and human liver biopsies, suggest that targeting a receptor found predominantly in the liver could help protect against the build-up of fat, halting...
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‘Triple G’ Agonist Hits New Weight-Loss Heights
Mitchel L. Zoler, PhD August 09, 2023 A novel triple agonist to receptors for three nutrient-stimulated hormones led to weight loss as high as 24% among people with overweight or obesity but who did not have type 2 diabetes when used at the highest tested dose for 48 weeks. The results are from a phase 2 study of retatrutide that was published in The New...
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Odds of clinically meaningful weight loss low in adults with overweight, obesity
by Lori Solomon Among adults with overweight or obesity, the annual probability of weight loss of 5 percent or more was achieved by only one in 10, according to a study published online Aug. 7 in JAMA Network Open. Lyudmyla Kompaniyets, Ph.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues assessed...
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Time-Restricted Eating Gains for Weight and Glycemic Control
Mitchel L. Zoler, PhD August 03, 2023 Time-restricted eating (TRE) can be a practical, easy-to-follow way for some people to control their daily food intake and lose weight. It precludes a person’s need to pay close attention to how much they eat as long as they confine consumption to a limited time window. Plus, results from several...
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New research offers prospects to measure metabolic rate
by Skolkovo Institute of Science and Technology Deuterium uptake in different organs of mice for various classes of lipids. Credit: International Journal of Molecular Sciences Scientists from Skoltech Institute of Science and Technology have proven that along with the level of biochemical substances in the living organism, we can also measure the substances’ turnover rate. This...