Nathalie Raffier July 13, 2023 MARSEILLE, France — Setmelanotide can lead to significant weight loss that lasts for at least 3 years, according to results presented at the latest French Pediatric Society conference. The treatment is effective for adults and children alike. Setmelanotide is the culmination of two decades of research involving the identification of genes involved...
Category: <span>Metabolic</span>
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Can Berberine Live Up to the Claim That It’s ‘Nature’s Ozempic’?
Lori Youmshajekian July 12, 2023 Berberine, a plant-derived compound historically used in traditional Chinese medicine, is experiencing increased popularity thanks to social media, especially TikTok, where the hashtag #berberine has more than 75 million views at the time of writing. Social media influencers are promoting the compound, calling it “Nature’s Ozempic,” saying they lost weight taking the supplement. Off-the-shelf berberine...
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New study reveals a key role of mRNA metabolism determinants in aging and disease
by Foundation for Research and Technology – Hellas Credit: Foundation for Research and Technology – Hellas A new research study at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology-Hellas (FORTH), published today in The EMBO Journal, reveals an intricate mechanism that impacts aging by controlling the number and the metabolic activity of mitochondria. Mitochondria are specialized organelles that...
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One third of normal-weight individuals are obese
TEL-AVIV UNIVERSITY IMAGE: PROF. YFTACH GEPNER CREDIT: TEL AVIV UNIVERSITY Researchers at Tel Aviv University found that the widely used Body Mass Index (BMI) measurement is less sensitive to define obesity than we thought. The researchers recommend equipping clinics with devices for measuring body fat percentage and ultimately turning this index into the gold standard of obesity (to...
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Triple Agonist Retatrutide Hits New Weight-Loss Highs
Mitchel L. Zoler, PhD June 26, 2023 SAN DIEGO — New designer molecules that target weight loss via multiple mechanisms continue to raise the bar of how many pounds people with overweight or obesity can lose. Retatrutide (Eli Lilly), an investigational agent that combines agonism to three key hormones that influence eating and metabolism into a single...
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Acetate controls endothelial-to-mesenchymal transition: Potential therapeutic target for reducing atherosclerosis
by Yale School of Medicine In a new study, researchers including Yale School of Medicine’s Michael Simons, MD, identify the molecular underpinnings of persistent endothelial-to-mesenchymal transition (EndMT), an important process related to vascular inflammation in diseases including pulmonary hypertension. Researchers found atypical acetate production from glucose triggered metabolic modulation of the endothelium activated TGF-β signaling, triggering a...
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Meta-analysis explores the mechanism that connects cancer and diabetes
by University of Copenhagen Credit: Pixabay/CC0 Public Domain Back in the 1920s, researchers discovered that cancer patients had sweet-smelling urine. First, the doctors were puzzled, but they soon realized that it was a result of elevated blood sugar levels. “This was one of the first things we learned about cancer patients,” says Associate Professor Lykke Sylow. The sweet-smelling...
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Metformin’s role in preventing metabolic syndrome during androgen deprivation therapy
by Impact Journals LLC Variable changes in phosphorylation of S6 kinase 1 was observed in both cohorts. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28458 A new research paper titled “Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer” has been published in Oncotarget ....
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Why Most People Regain Lost Weight? Obesity Severely Impairs the Brain’s Response to Nutrients
By AMSTERDAM UNIVERSITY MEDICAL CENTERS JUNE 18, 2023 New research indicates that brain responses to nutrients are diminished in people with obesity and don’t improve even after weight loss. The study revealed that individuals with obesity released less dopamine in a brain region crucial for food intake motivation, compared to those with healthy body weight. Additionally, obese participants showed...
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Treating menopause symptoms: Medications, lifestyle & self-care
by Ann Schreiber Navigating the changes and discomforts of menopause can be a frustrating experience for many women. Daily life can be significantly affected by symptoms ranging from hot flashes and mood swings to sleep disturbances and vaginal dryness. Treating those symptoms may require a mix of approaches, including medication, lifestyle adjustments and self-care strategies....