by Boston University School of Medicine Regulation of thyroid hormone (TH) levels is a complex multilevel phenomenon. The paraventricular nucleus (PVN) of the hypothalamus (the region of the brain that controls the involuntary nervous system) has been identified as a direct regulator of thyrotropin (a hormone secreted by the pituitary gland that regulates the production of...
Category: <span>Metabolic</span>
Study reveals how treatment-resistant prostate cancer provides its own hormonal fuel
by Julia Evangelou Strait, Washington University in St. Louis Thin slice of a human prostate tumor. The dark staining throughout reveals the presence of histone acetylation promoting cholesterol production. Cholesterol is required to make testosterone, which fuels tumor growth. Credit: Nupam Mahajan/School of Medicine A new study in mice, led by researchers at Washington University School...
Cutting breakfast carbs can benefit people with type 2 diabetes, study confirms
by University of British Columbia Credit: CC0 Public Domain An international team, led by UBC Okanagan researchers, suggests a simple tweak to the first meal of the day might help people living with type 2 diabetes (T2D) better control their blood sugar levels. Dr. Barbara Oliveira conducts research with Dr. Jonathan Little’s Exercise, Metabolism and Inflammation...
Understanding of fat cells could lead to calorie-burning treatments
Researchers hope someday to be able to tell fat cells to burn off excess calories as heat, instead of storing them and causing people to become overweight or obese. REUTERS/Finbarr O’Reilly. Understanding of fat cells could lead to calorie-burning treatments Researchers are a step closer to figuring out how to instruct fat cells to burn off excess...
A new player unveiled for lipid oxidation
HIGHER EDUCATION PRESS IMAGE: THE SYMPATHETIC NERVOUS SYSTEM RELEASES THE NEUROTRANSMITTER NOREPINEPHRINE (NE) AND ACTIVATES THE Β3 ADRENERGIC RECEPTOR (ADRB3) PATHWAY FOR LIPID HYDROLYSIS AND OXIDATION IN RESPONSE TO COLD EXPOSURE. THIS UPREGULATES THERMOGENIC GENES, INCLUDING UNCOUPLING PROTEIN 1 (UCP1), WHICH MEDIATES THE THERMOGENIC PROCESS. ADDITIONALLY, OGFR ENHANCES THE PRODUCTION OF THE MITOCHONDRIAL TRIFUNCTIONAL PROTEIN...
The majority of thyroid patients still suffering years on from diagnosis
by University of Aberdeen Credit: Pixabay/CC0 Public Domain Diagnosis is only the start of a lengthy journey for the majority of thyroid disease patients, according to new research exploring people’s experience of living with the condition. Marking World Thyroid Day on 25 May, researchers at the University of Aberdeen have released the findings of a survey...
MAIT cells can be tuned to fight different pathogens via their metabolism, leading to new therapeutic strategies
by La Jolla Institute for Immunology Credit: Pixabay/CC0 Public Domain A population of unconventional white blood cells has recently captured the attention of immunologists and clinicians alike. Unlike conventional T cells, which circulate throughout the body in our blood, mucosal-associated invariant T (MAIT) cells are largely found in tissues where they provide immune protection against a...
New study shows 1 in 5 ‘healthy’ individuals actually have the metabolism of a prediabetic
by Klick Applied Sciences Credit: Pixabay/CC0 Public Domain Scientists at Klick Labs have developed a new way to catch the earliest signs the human body is failing to control blood glucose levels before they reach prediabetic levels in patients. In findings published today in Mayo Clinic Proceedings: Digital Health, researchers have outlined a new method of analysis that...
Women appear to be more resilient to body clock disruptions than men, says new research
by Timothy Hearn, The Conversation One of the most common causes of circadian misalignment is shift work. Credit: Ground Picture/Shutterstock You might not know it, but we all have a clock ticking away inside us. This circadian clock operates on roughly a 24-hour cycle. It influences when we sleep, wake and eat, among other things. However, our body clock...
Toxins from gut damage fat cells and drive weight gain, study suggests
PA Media Sun 21 May 2023 01.00 EDT Fragments of bacteria leaking into the body from the gut are damaging fat cells and driving weight gain, research suggests. Scientists at Nottingham Trent University have found that these microbe fragments, known as endotoxins, are able to enter the bloodstream and directly affect how well fat cells...