A gene mutation causes wrinkled skin and hair loss; turning off that mutation restores the mouse to normal appearance UNIVERSITY OF ALABAMA AT BIRMINGHAM BIRMINGHAM, Ala. – Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed? IMAGE: THE MOUSE IN THE CENTER PHOTO SHOWS AGING-ASSOCIATED SKIN WRINKLES AND HAIR LOSS...
Category: <span>Mitochondrial Protease Therapy</span>
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Mitochondrial dysfunction contributes to kidney disease
Scientists found a previously unknown link between mitochondria and kidney disease, identifying a receptor that causes kidney dysfunction when suppressed, according to a study published in Proceedings of the National Academy of Sciences. The receptor—estrogen-related receptor gamma (ERRγ)—regulates mitochondrial metabolism, and was also found in unusually low levels in patients with chronic kidney disease, pointing to its...
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Bowel disease study points to new therapies for lifelong conditions
Treatments for incurable bowel conditions may be a step closer following the discovery of a key molecule associated with disease flare-ups. Researchers say the finding helps to explain the underlying cause of disorders such as Crohn’s disease and ulcerative colitis. The discovery could also lead to new tests to help doctors monitor patients’ condition and help...
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Scientists identify a promising target for the treatment of heart failure
Stained heart sections from wild-type mice and knockout mice that do not express OMA1. Wild-type mice exposed to ISO, which induces heart failure, exhibited collagen lesions indicative of heart cell death (top right), while knockout mice Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) led by Dr. José Antonio Enríquez have described...