by Texas A&M University Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Texas A&M University College of Medicine ressearchers have recently discovered that cytisine—a smoking cessation drug commonly used in Europe—reduces the loss of dopamine neurons in females. These findings provide potential evidence for...
by Osaka City University (A) The neuroprotection by sesaminol. ARE: antioxidant response element, EpRE: electrophile responsive element, ROS: reactive oxygen species, NQO1: NAD(P)H: quinone oxidoreductase, HO-1: hemo oxygenase-1, ?-GCS:??-glutamylcysteine synthetase(B) Effects of sesaminol and 6-OHDA on the viability of SH-SY5Y cells.SH-SY5Y cells were incubated with 0.25~10 ?g/ml of sesaminol for 2 h, followed by treatment...
by University of Cambridge 3D illustration showing neurons containing Lewy bodies small red spheres which are deposits of proteins accumulated in brain cells that cause their progressive degeneration. Credit: Kateryna Kon via Shutterstock A study published in Nature Communications today presents a compelling new evidence about what a key protein called alpha-synuclein actually does in neurons in the...
IOS PRESS Amsterdam, NL, February 3, 2021 – Patients with Parkinson’s disease (PD) and healthcare professionals caring for them have expressed concerns about the COVID-19 vaccine’s efficacy and safety in the specific context of PD and its symptomatic treatment. In a commentary just published in the Journal of Parkinson’s Disease, a set of experts addresses these concerns from...
VAN ANDEL RESEARCH INSTITUTE GRAND RAPIDS, Mich. (Feb. 2, 2021) — What does bile acid production in the digestive tract have to do with Parkinson’s disease? Quite a lot, according to a sweeping new analysis published in the journal Metabolites. The findings reveal that changes in the gut microbiome — the rich population of helpful microbes that call the...
by University of Pennsylvania Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Many genetic mutations have been found to be associated with a person’s risk of developing Parkinson’s disease. Yet for most of these variants, the mechanism through which they act remains unclear. Now...
UNIVERSITY COLLEGE LONDON Simple vision tests can predict which people with Parkinson’s disease will develop cognitive impairment and possible dementia 18 months later, according to a new study by UCL researchers. The study, published in Movement Disorders, adds to evidence that vision changes precede the cognitive decline that occurs in many, but not all, people with...
by Nagoya University Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons and characterized by motor signs including bradykinesia, rigidity, resting tremor, and reduced postural reflex. More than 50% of dopaminergic neurons in the substantia nigra are lost at the onset of motor symptoms in PD. Prodromal symptoms, such as dysautonomia,...
by American Associates, Ben-Gurion University of the Negev Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Ben-Gurion University of the Negev researchers have discovered that the protein BMP5/7 offers promising therapeutics that could slow down or halt the progression of Parkinson’s disease. The findings were published...
UNIVERSITY OF VIRGINIA HEALTH SYSTEM IMAGE: JEFF ELIAS, MD, IS A NEUROSURGEON AT UVA HEALTH AND A PIONEER IN THE FIELD OF FOCUSED ULTRASOUND. CREDIT: UVA HEALTH A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson’s disease symptoms that are much more severe on one side of the body, new research suggests. ...
