UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES Research from UCLA scientists and colleagues from other institutions finds that people with Parkinson’s disease who lack meaningful social interactions may be at an increased risk for severe symptoms related to the disease. The study, which was published in the journal NPJ Parkinson’s Disease, evaluated not only the...
Category: <span>parkinsons</span>
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How molecular chaperones dissolve protein aggregates linked to Parkinson’s disease
by Heidelberg University Disaggregation of α-synuclein amyloid fibrils relies on the cooperation of the HSP70 chaperone with its co-chaperones DNAJB1 and HSP110. This cooperation ensures recognition of the fibrils, followed by the correct assembly of the Hsp70 disaggregase machinery on the fibril surface thereby allowing for productive disaggregation. In many neurodegenerative diseases like Parkinson’s, protein aggregates...
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Learning disorders and Parkinson’s disease: Tremor predicts effects of medication
by Radboud University Nijmegen Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. The effect of dopaminergic medication on the learning abilities of patients with Parkinson’s disease turns out to be linked to the presence of tremor symptoms. In patients who do not experience tremor, dopaminergic medication...
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Common diabetes drugs may prevent Parkinson’s
by University College London Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Elevated risk of Parkinson’s disease among people with type 2 diabetes appears to be reduced by some medications used to treat their diabetes, finds a new study led by UCL researchers. The researchers are testing one of...
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Nausea drugs could help alleviate hallucinations in people with Parkinson’s
As society in the West is aging, more and more people are going to suffer from age-related illnesses, such as Parkinson’s disease. This terrible condition is already affecting millions and, of course, it is incurable. Around three quarters of Parkinson’s patients experience hallucinations, which can sometimes be triggered by medication used to tread other symptoms....
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Diagnosing Parkinson’s disease with skin samples could lead to earlier detection
IOWA STATE UNIVERSITY IMAGE: ANUMNATHA KANTHASAMY AMES, Iowa – New research shows a simple skin test can accurately identify Parkinson’s disease, demonstrating for the first time the feasibility of the method. Currently diagnosed by clinical signs and symptoms but only definitively diagnosed at autopsy, Parkinson’s disease is commonly misdiagnosed early in the disease course, complicating clinical trials...
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Gut hormone blocks brain cell formation and is linked to Parkinson’s dementia
SWANSEA UNIVERSITY A gut hormone, ghrelin, is a key regulator of new nerve cells in the adult brain, a Swansea-led research team has discovered. It could help pave the way for new drugs to treat dementia in patients with Parkinson’s Disease. Blood-borne factors such as hormones regulate the process of brain cell formation – known as neurogenesis...
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Excess lipids in nerve cells may trigger Parkinson’s disease
Researchers have discovered an imbalance in the amounts of fatty molecules called lipids inside the brain cells of people with Parkinson’s disease. A buildup of lipids in nerve cells may cause inflammation. Parkinson’s disease is a movement disorder that gets progressively worse over time. The death of dopamine-producing nerve cells in the substantia nigra region of...
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Scientists uncover new clues about Parkinson’s disease
Tool developed at MIT simultaneously measures chemical and electrical brain signals, revealing unexpectedly complex relationship between brain signals. As the brain processes information, electrical charges zip through its circuits and neurotransmitters pass molecular messages from cell to cell. Both forms of communication are vital, but because they are usually studied separately, little is known about...
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New study may reveal link to lipids playing a key role in Parkinson’s disease
by McLean Hospital Researchers in the Neuroregeneration Institute are making strides in Parkinson’s disease research. In a novel research study conducted by a team from the Neuroregeneration Institute at McLean Hospital, investigators believe they have found key brain cell type changes involving lipids, inflammation, and the development of Parkinson’s disease (PD). Their findings appear in the current issue...