By Osman Shabir, M.Sc. Reviewed by Dr. Mary Cooke, Ph.D. Parkinson’s disease is a neurodegenerative disorder clinically characterized by resting tremor, bradykinesia (slow movements), dyskinesia (impairment of movement), dystonia (stiffness of muscles including facial muscles), a stooped posture, sexual and urinary dysfunction, drooling, and in some cases psychiatric symptoms including psychosis, dementia, and depression Pathologically,...
Medicine RUHR-UNIVERSITY BOCHUM The team was thus able to provide further evidence that there are interfaces between the nervous system and immune system. The researchers hope that the protagonists or antagonists of this signalling pathway may be suitable for therapeutic interventions. They report on this in the cover story in the journal Science Signalingon 4...
by Washington University School of Medicine Dementia is one of the most debilitating consequences of Parkinson’s disease, a progressive neurological condition characterized by tremors, stiffness, slow movement and impaired balance. Eighty percent of people with Parkinson’s develop dementia within 20 years of the diagnosis, and patients who carry a particular variant of the gene APOE...
by University of Texas Health Science Center at Houston Scientists have found a way to distinguish between two progressive neurodegenerative diseases, Parkinson’s disease (PD) and multiple system atrophy (MSA), using a technology developed by a researcher at The University of Texas Health Science Center at Houston (UTHealth). The discovery was published today in Nature. It is...
by Cedars-Sinai Medical Center People who develop Parkinson’s disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new Cedars-Sinai research. The research points to a drug that potentially might help correct these disease processes. Parkinson’s occurs when brain neurons that make dopamine, a substance that...
by KU Leuven Biomedical scientists at KU Leuven have discovered that a defect in the ATP13A2 gene causes cell death by disrupting the cellular transport of polyamines. When this happens in the part of the brain that controls body movement, it can lead to Parkinson’s disease. Parkinson’s disease is one of the most common neurodegenerative...
by Charlotte Hsu, University at Buffalo Research by University at Buffalo biologists is providing new insights into alpha-synuclein, a small acidic protein associated with Parkinson’s disease. Alpha-synuclein is known to form abnormal clumps in the brains of patients with Parkinson’s, but scientists are still trying to understand how and why this happens. The new study...
by IOS Press Overview of the currently included countries in the IPDGC and IPDGC-affiliated efforts. IPDGC = International Parkinson Disease Genomics Consortium, LARGE-PD = Latin American Research Consortium on the Genetics of Parkinson Disease, Lux GIANT = Luxembourg-German-Indian Alliance on Neurodegenerative diseases and Therapeutics. Credit: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of...
The hallmark symptoms of Parkinson’s disease are motor symptoms that include shaking hands and slowness of movement, but specialists still do not entirely understand what causes this disease. Newly published research may now overturn prevailing notions about key Parkinson’s mechanisms. Motor symptoms in Parkinson’s disease may be due to brain changes that take place earlier...
by The Chinese University of Hong Kong, Shenzhen A synthetic small molecule compound called AQAMAN can prevent and even reverse harmful protein build-up in neurons that is associated with several rare neurodegenerative disorders, including polyglutamine (or polyQ) diseases. People with polyQ diseases, such as Huntington’s and Machado-Joseph diseases, lose muscle control and coordination as nerve...
