by Melissa Rohman, Northwestern University Graphical abstract. Credit: DOI: 10.1016/j.celrep.2021.109975 Northwestern investigators have discovered the molecular signature of a subset of dopaminergic neurons with an increased vulnerability to degeneration. The findings shed light on the mechanisms at play within a small subsection of the brain’s substantia nigra, called the pars compacta, which contribute to the development...
by University of Bath Dr. Richard Meade. Credit: University of Bath A molecule that shows promise in preventing Parkinson’s disease has been refined by scientists at the University of Bath in the UK, and has the potential to be developed into a drug to treat the deadly neurodegenerative disease. Professor Jody Mason, who led the...
by Texas Biomedical Research Institute The small molecule PD13R (magenta) interacting with the dopamine D3 (grey) and D2 (purple) receptors cryo-EM structures, as predicted by RhodiumTM. Credit: SwRI A new study from Texas Biomedical Research Institute (Texas Biomed) and collaborators has identified a promising drug candidate to minimize uncontrolled, erratic muscle movements, called dyskinesia, associated...
by Will Doss, Northwestern University Endoplasmic reticulum (red) is small and malformed in Parkinson’s disease (left), but can be rescued with diltiazem and a farnesyl-transferase inhibitor (right). Credit: Northwestern University A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson’s disease-afflicted brain cells, according to a Northwestern Medicine study published in Neuron. Improving...
IMAGE: UVA HEALTH NEUROSURGEON JEFF ELIAS, PHD, HAS BEEN A PIONEER IN THE DEVELOPMENT OF FOCUSED ULTRASOUND FOR THE TREATMENT OF ESSENTIAL TREMOR, A COMMON MOVEMENT DISORDER, AND PARKINSON’S DISEASE. CREDIT: UVA HEALTH The federal Food and Drug Administration has approved an incisionless form of brain surgery to treat advanced Parkinson’s disease after successful testing...
by Georgetown University Medical Center Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia In an unexpected discovery, Georgetown University Medical Center researchers have identified what appears to be a significant vascular defect in patients with moderately severe Parkinson’s disease. The finding could help explain...
UNIVERSITY OF SEVILLE After years of research, data have been released about Parkinson’s disease that may change the course of the disease and consequently of the patients who suffer from it. On the one hand, the researchers conclude that it is insufficient to affect just part of the dopaminergic neurons (axons) as previously thought, but...
MEDICAL UNIVERSITY OF SOUTH CAROLINA IMAGE: DOPAMINE PRODUCING BRAIN CELLS (STAINED BROWN) WERE PROTECTED WITH HPPE (RIGHT PANELS) IN NEUROTOXIN-BASED PD MODEL (MPTP; BOTTOM) COMPARED TO VEHICLE CONTROL CELLS (LEFT PANELS). CREDIT: DR. BOBBY THOMAS FROM THE MEDICAL UNIVERSITY OF SOUTH CAROLINA. Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, afflicting more than...
by Medical University of South Carolina Dopamine producing brain cells (stained brown) were protected with HPPE (right panels) in neurotoxin-based PD model (MPTP; bottom) compared to vehicle control cells (left panels). Credit: Dr. Bobby Thomas from the Medical University of South Carolina. Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, afflicting more than 10...
by Jamie Wetherbe, University of Southern California Credit: Pixabay/CC0 Public Domain Until about 10 years ago, most clinicians only looked at the brain when finding ways to treat patients with Parkinson’s Disease. “Neurologists and researchers try to improve brain function and use treatment strategies that target the brain,” said Kaylie Zapanta MS ’17 Ph.D. ’23. “As an exercise physiologist, I’m...
