by University of Copenhagen Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Parkinson’s Disease develops if a certain anti-viral receptor and its protein in the brain, called the interferon-beta pathway, is not functioning correctly. That causes the pathway to be blocked, and as a...
by Graduate Center, CUNY A new study from Malave et al. suggests that in the brains of L-Dopa-treated Parkinson’s patients the lack of Shh signaling to cholinergic neurons results in L-Dopa induced dyskinesia. Credit: Santiago Uribe-Cano. Levodopa, or L-dopa, is considered the most effective treatment for Parkinson’s disease today. After a few years of treatment, however,...
Share on Pinterest A recent study has investigated the strategies that people with Parkinson’s use to walk more easily. Solskin/Getty Images People with Parkinson’s disease who have trouble walking often invent ways to help them manage the changes to their gaits. A new study suggests that familiarity with these techniques should be more widespread. There...
by University of Connecticut Credit: Yulan Xiong Mutations in a protein known to cause Parkinson’s Disease derange transportation in and out of brain cells, reports a team of UConn Health researchers in the 27 July issue of Science Signaling. The toxic traffic jams that result eventually lead to certain brain cell death and the characteristic symptoms of Parkinson’s. “We...
By Michael Irving September 07, 2021 Tiny lab-grown mini-brains have now been induced to show pathology features of Parkinson’s disease Associate Professor Hyunsoo Shawn Je, Duke-NUS Medical School. To help us crack the complex puzzle that is our own brains, scientists have been growing miniature versions in the lab. Now, a team in Singapore has...
by Foundation for Research and Technology – Hellas Graphical abstract. Credit: Foundation for Research and Technology – Hellas International scientific collaboration between Researchers at the Institute of Molecular Biology & Biotechnology of FORTH, and Scientists at the National and Kapodistrian University of Athens and the University of Oslo, in Norway, has uncovered the novel role of the DNA base excision...
by Gladstone Institutes Gladstone researchers, including Ken Nakamura (left), Zak Doric (center), and Huihui Li (right), tracked mitochondria inside neurons and uncovered a new recycling pathway that may be linked to Parkinson’s disease. Credit: Michael Short/Gladstone Institutes Scientists have long known that living cells are master recyclers, constantly breaking down old parts and building them back up...
by Haley Wasserman, Johns Hopkins University School of Medicine Researchers at Johns Hopkins Medicine have pinpointed the section of a brain protein called alpha-synuclein that enables it to latch onto neurons and likely drives the development of Parkinson’s disease, a progressively worsening neurological disorder. The photomicrograph shows an aggregation of alpha-synuclein in brain tissue taken from...
by Johns Hopkins University School of Medicine Credit: Pixabay/CC0 Public Domain Johns Hopkins Medicine researchers say they have added to evidence that the compound farnesol, found naturally in herbs, and berries, and other fruits, prevents and reverses brain damage linked to Parkinson’s disease in mouse studies. The compound, used in flavorings and perfume-making, can prevent the...
INSTITUT PASTEUR Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases’ pathogenesis, which is essential to develop efficient treatments against these incurable diseases. However, our knowledge about the basic molecular mechanisms underlying the pathogenesis of neurodegenerative...
