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Chung-Ang University researchers identify a potential anti-aging drug

News Release 25-Sep-2024 Scientists investigated a drug namely IU1 for mitigating age-related problems in protein quality control systems Peer-Reviewed PublicationChung Ang University Using fruit flies as an animal model, researchers shed light on the synergistic effects of two different mechanisms by which cells destroy faulty proteins that lead to aging. Moreover, by administering a modern...

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Pipeline of new drug treatment for non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease

News Release 25-Sep-2024 Peer-Reviewed PublicationXia & He Publishing Inc. ACC, Acetyl-CoA Carboxylase; PPAR, peroxisome proliferator–activated receptor; MPC, mitochondrial pyruvate carrier; THR, thyroid hormone receptor; ASK-1, apoptosis signaling kinase-1; GLP-1R, glucagon-like peptide-1 receptor; GCGR, glucagon receptor; GIPR, glucose-dependent insulinotropic polypeptide receptor; PDE, phosphodiesterase; SGLT, sodium–glucose cotransporter; FXR, farnesoid X receptor; SCD1, stearoyl-CoA desaturase 1; FGFR4/1, fibroblast...

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Johnson & Johnson seeks first approval of nipocalimab to treat broadest population living with antibody positive generalized myasthenia gravis

From Johnson & JohnsonSep 24 2024 Johnson & Johnson today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) seeking the first approval of nipocalimab globally for the treatment of people living with generalized myasthenia gravis (gMG). The application included data from the Phase 3 Vivacity-MG3 study...

Fibrosis lacks treatments and methods of reversal: Study pinpoints a promising target for drug therapy
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Fibrosis lacks treatments and methods of reversal: Study pinpoints a promising target for drug therapy

September 23, 2024 by Delthia Ricks , Medical Xpress Model of MERTK mechanisms for regulating TGFβ core fibrotic pathway across various organs. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adj0133Medical science has long been on the hunt for a deeper understanding of the devastating scarring of the body’s organs known as fibrosis, which leads to irrevocable...

Certain antidepressants may improve brain function, study finds
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Certain antidepressants may improve brain function, study finds

September 23, 2024 by European College of Neuropsychopharmacology Credit: Wikimedia CommonsResearchers have found that SSRI (selective serotonin reuptake inhibitor) antidepressants have the potential to improve certain cognitive functions, such as verbal memory. They measured brain function in patients before and after taking the SSRI, escitalopram, and correlated this to a drop in the level of...

Small-molecule drug shows potential for hard to treat cancers
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Small-molecule drug shows potential for hard to treat cancers

September 23, 2024 by University of Dundee Credit: Unsplash/CC0 Public DomainExperts from the University of of Dundee’s Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a “protein degrader.” KRAS is the most mutated gene in cancer with mutations occurring in 17%–25% of all cancers, affecting millions...

New migraine drugs no better than cheap painkillers: big study
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New migraine drugs no better than cheap painkillers: big study

September 21, 2024 Credit: Unsplash/CC0 Public DomainNew, more expensive migraine drugs are no more effective against the throbbing headaches than traditional painkillers, and even performed worse than an older range of treatments called triptans, said a massive global analysis Thursday. Migraines are severe, often disabling headaches which affect at least one in seven adults globally,...

Study shows cholesterol enhances exosome-mediated RNA drug delivery
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Study shows cholesterol enhances exosome-mediated RNA drug delivery

September 20, 2024 by Liu Jia, Chinese Academy of Sciences Cholesterol-enriched exosomes merged with the cell surface. Credit: Gan’s labRNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short...

Antidepressant shows promise for treating brain tumors
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Antidepressant shows promise for treating brain tumors

September 20, 2024 by ETH Zurich Credit: Sohyon Lee and Berend Snijeder / ETH ZurichGlioblastoma is a particularly aggressive brain tumor that at present is incurable. Cancer doctors can extend patients’ life expectancy through operations, radiation, chemotherapy or surgical interventions. Nevertheless, half of patients die within twelve months of diagnosis. Drugs that are effective against...