Previous studies have demonstrated that the alcohol abuse drug disulfiram has anticancer properties. But until now, researchers had not found the mechanism by which the drug can target cancer. New research sheds light, paving the way for the repurposing of the drug. The drug disulfiram can help to kill off cancer cells. A new study —...
Category: <span>Pharmaceutical Updates</span>
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Food? Drug? The FDA says this capsule could cause deadly liver and lung problems
After reports of “two serious and potentially life-threatening medical conditions,” the FDA this week issued a consumer alert for osteoarthritis capsule Limbrel. The alert: Don’t take it. And that came as a surprise to Limbrel manufacturer Primus Pharmaceuticals. “They visited our offices on Nov. 8, as they said in the alert, then spent four days...
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Tapeworm drug could lead the fight against Parkinson’s disease
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Researchers at Cardiff University, in collaboration with the University of Dundee, have identified a drug molecule within a medicine used to treat tapeworm infections which could lead to new treatments for patients with Parkinson’s disease. Parkinson’s...
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Existing cancer medication offers potential to treat Huntington’s disease
A drug already used to treat certain forms of cancer may also be an effective therapy for Huntington’s disease, according to a new study in the latest issue of Science Translational Medicine. The same study also increases our understanding of how this drug, and other medications like it, may offer hope for other neurodegenerative diseases like...
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Experimental Drug Blocks Toxic Ion Flow Linked to Alzheimer’s Disease
An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer’s disease. The drug works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer’s...
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Dibenzoazepine found to be effective against resistant hepatitis C
(Upper panel) Val223 and Phe258 of SPP interacts with the inhibitors for SPP and γ-secretase. (Lower panel) The inhibitor prevents proliferation of protozoa in toxoplasma infected mice. The inhibitor also ameliorates liver steatosis induced. Hepatitis C is caused by a highly infectious virus affecting millions across the globe and can lead to a variety...
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A risk factor for drug-induced skin disease identified
Researchers have identified a type of human leukocyte antigen (HLA) that is associated with the skin disease bullous pemphigoid (BP) in diabetic patients administered with DPP-4 inhibitory drugs. IMAGE: THESE ARE NON-INFLAMMATORY BULLOUS PEMPHIGOIDS (BP) SEEN IN THE TYPE 2 DIABETES PATIENT WHO ARE ADMINISTERED WITH DPP-4 INHIBITOR. DPP-4 inhibitor (DPP-4i) is widely used to...
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Exclusive: Sexual harassment inside biotech’s biggest hedge fund
Sam Isaly, the founder of biotech’s largest and most powerful hedge fund, has for years perpetuated a toxic culture of sexual harassment, former employees told STAT, routinely subjecting young female assistants to pornography in the workplace, lewd jokes, and pervasive sexist comments. One woman said on several occasions, she glimpsed hardcore pornography playing on the...
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First two-drug HIV treatment regimen gets US FDA approval
A new therapy called Juluca became the first two-drug treatment for HIV to get the FDA’s approval on Tuesday Juluca uses two active ingredients previously approved by the FDA to keep HIV viral loads at an undetectable level The new drug is part of a wave of innovative therapies attempting to make HIV treatment regimens...
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Over-the-counter supplement found on the High Street reduces breast cancer aggressiveness by up to 80%, breakthrough study finds
NAC, approved for colds, lowers levels of cancer aggressiveness marker MCT4 MCT4 is reduced by 80%, while the aggressive marker Ki67 decreases by 25% Drug contains antioxidants that make tumors release nutrients, stopping growth Low-toxicity treatment as its acceptable side effects have been shown in colds Researchers from the University of Salford analysed 12 breast cancer...