EGFR is a common genetic target in lung cancer, but not all EGFR mutations are created equal. Patients with a type of EGFR anomaly called an “EGFR exon 20 insertion” often fail to respond to existing drugs targeting EGFR. Previous work shows this is because it simply takes a much higher concentration of anti-EGFR drugs...
Category: <span>Pharmaceutical Updates</span>
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Less than half of patients prescribed new cholesterol drug receive insurance approval
Less than half of patients received their insurer’s approval for prescriptions of PCSK9 inhibitors, according to new research in the American Heart Association’s journal Circulation. PCSK9 inhibitors, like Repatha (evolocumab) and Praluent (alirocumab), work by increasing the removal of low-density lipoprotein (LDL) or “bad” cholesterol from the blood. They have been shown to reduce LDL by...
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Incretin tied to better outcomes in NOCS-diabetes
(HealthDay)—Incretin treatment appears to improve non-ST-elevation myocardial infarction (NSTEMI) outcomes in patients with type 2 diabetes and non-obstructive coronary artery stenosis (NOCS), according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism. Raffaele Marfella, M.D., Ph.D., from Università degli Studi della Campania in Italy, and colleagues compared the 12-month prognosis of individuals with...
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New patent will allow for the relief of chronic neuropathic pain
University of Seville and GB Sciences Inc. members meet to license the patent. The researchers Lucía Martín Banderas and Mercedes Fernández Arévalo, from the I+DNanomed research group at the University of Seville, have patented an innovative formulation based on nanotechnology, which is designed to relieve chronic neuropathic pain. The company GB Sciences, Inc. has...
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New diabetes drug may also treat obesity
Test subjects lost an average of 5 kg (11 lb) over 12 weeks, when taking semaglutide Semaglutide is a compound that’s already being developed as a treatment for diabetes, by Danish pharmaceutical company Novo Nordisk. According to a new study conducted by scientists from the University of Leeds, however, it may serve another valuable purpose...
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Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
1 ) LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, P-4169-007 Porto, Portugal 2 ) Ciências Químicas e das Biomoléculas, Escola Superior de Saúde–Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 400, P-4200-072 Porto, Portugal 3 ) i3S–Instituto de Investigação e Inovação em Saúde, Universidade do Porto,...
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The End of Pneumonia? New Vaccine Offers Hope
BUFFALO, N.Y. — In 2004, pneumonia killed more than 2 million children worldwide, according to the World Health Organization. By 2015, the number was less than 1 million. Better access to antibiotics and improved nutrition account for part of the decline. But scientists say it’s mostly due to vaccines introduced in the early 2000s that...
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New target emerging for treating diabetes-related blood vessel damage
Dr. Masuko Ushio-Fukai, vascular biologist in the Vascular Biology Center at the Medical College of Georgia at Augusta University. A key enzyme that helps our proteins fold and function properly may also be a good therapeutic target to improve blood vessel health in diseases like diabetes and atherosclerosis, scientists say. The enzyme is protein...
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A step closer to a cure for adult-onset diabetes
Pernilla Wittung Stafshede, Professor and head of the Chemical Biology division at the Department of Biology and Biological Engineering. She heads a research team focusing on metalloproteins and proteins that fold incorrectly. Previously, …more In healthy people, exosomes – tiny structures secreted by cells to allow intercellular communication – prevent clumping of the protein that...
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Patients at risk over failure to recognize important diabetes subtype
The health of people with diabetes is being put at risk due to the failure of doctors to recognise which type of diabetes they have, a new study in the journal Diabetes Care reports. In the first ever study of its kind, researchers from the University of Surrey, examined the primary care records of more than 2...