Defective protein folding causes nervous system diseases in humans and hinders the proper functioning of the chloroplasts in plants The chloroplasts containing misfolded protein aggregates send a SOS signal to the cell nucleus, where a molecular switch is turned on to activate the chaperone synthesis. Various human nervous system diseases, such as amyotrophic lateral sclerosis...
Category: <span>Pharmaceutical Updates</span>
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Ketamine may help treat migraine pain unresponsive to other therapies
Ketamine, a medication commonly used for pain relief and increasingly used for depression, may help alleviate migraine pain in patients who have not been helped by other treatments, suggests a study being presented at the ANESTHESIOLOGY® 2017 annual meeting. The study of 61 patients found that almost 75 percent experienced an improvement in their migraine...
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Sleeping sickness can now be cured with pills
For the first time, researchers have cured the deadly neurological disease sleeping sickness using pills instead of a combination of intravenous infusions and pills. The investigators presented the results from final clinical trials on 17 October at the European Congress on Tropical Medicine and International Health in Antwerp, Belgium, providing hope that the treatment will help to...
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Can aspirin stop liver cancer in hepatitis B patients?
(HealthDay)—Daily aspirin may reduce the risk of liver cancer for people with hepatitis B infection, a new study suggests. Hepatitis B virus attacks the liver and can cause cirrhosis and liver cancer. Previous research suggests daily low-dose aspirin therapy may prevent cancer, but there is little clinical evidence on whether regular aspirin use can prevent liver cancer...
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Scientists May Have Discovered a “Functional Cure” for HIV
IN BRIEF Scientists from The Scripps Research Institute have conducted research into a new way to treat HIV. Their method involves using a compound to subdue the virus’ production and re-activation, which has been successfully tested in mice. SUPPRESSING HIV Science has proposed multiple ways to rid the body of HIV, such as through careful surgery or gene...
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Colorectal cancer: New, less toxic drug target uncovered
A team of researchers at the Francis Crick Institute in London, in the United Kingdom, set out to explore novel therapeutic options for treating bowel cancer. They found a drug target that promises to be less toxic than existing drugs. In the United States, colorectal cancer is expected to affect 135,430 people in 2017, according to the American Cancer Society (ACS)....
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One step closer toward a treatment for Alzheimer’s disease?
Novel class of drugs more precisely blocks production of toxic forms of beta-amyloid Scientists at the Massachusetts General Hospital (MGH), in collaboration with colleagues at the University California, San Diego (UCSD), have characterized a new class of drugs as potential therapeutics for Alzheimer’s disease and discovered a piece in the puzzle of how they would...
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A new kind of influenza vaccine: One shot might do the trick
Researchers Matt DeLisa, left, Gary Whittaker and David Putnam are pictured in DeLisa’s Olin Hall lab. A seasonal flu shot is a bit like a local weather forecast: Based on the conditions elsewhere and the direction of the prevailing wind, a meteorologist can give the public a pretty good idea of what to expect in...
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Stages of Drug Discovery & Development
Bio-Rad offers products and services that accelerate the entire drug discovery and development cycle, from target identification through scale-up and manufacturing. Browse our featured resources or request a consultation with one of our Pharma specialists to talk about how Bio-Rad can support your specific needs. TARGET DISCOVERY Whether your targets are proteins, nucleic acids, lipids,...
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Gel that can stop your knees become arthritic: Treatment encourages growth of cartilage by stopping scar tissue from forming
A new gel to prevent the damage that leads to arthritic knees is being tested The treatment aims to encourage the growth of cartilage that absorbs shocks The new gel, called GelrinC, acts as a highly dense scaffold, working as a barrier A high-tech gel to prevent the damage that leads to arthritic knees is...