Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis Pairing the antibiotic ceftazidime with the enzyme inhibitor avibactam may be an effective treatment for drug-resistant tuberculosis, a new study reports. This antibacterial drug combination – already in clinical use for Gram-negative bacterial infections – could aid in stemming the growing global drug-resistant tuberculosis crisis. Mycobacterium tuberculosis (or...
Category: <span>Pharmaceutical Updates</span>
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Discovery of drug combination: Overcoming resistance to targeted drugs for liver cancer
A KAIST research team presented a novel method for improving medication treatment for liver cancer using Systems Biology, combining research from information technology and the life sciences. Professor Kwang-Hyun Cho in the Department of Bio and Brain Engineering at KAIST conducted the research in collaboration with Professor Jung-Hwan Yoon in the Department of Internal Medicine...
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Chemo-boosting drug discovered for leukemia
Drugs developed to treat heart and blood vessel problems could be used in combination with chemotherapy to treat an aggressive form of adult leukemia, new research led by the Francis Crick Institute reveals. In a study published in Cancer Cell, researchers at the Francis Crick Institute, King’s College London and Barts Cancer Institute discovered that acute myeloid...
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Researchers find beta blockers have positive effect in pulmonary arterial hypertension
A team of Cleveland Clinic researchers found that a common heart disease medication, beta blockers, may help treat pulmonary arterial hypertension (PAH), a debilitating lung disease. Caused by high blood pressure in the pulmonary arteries, PAH is a progressive disease which usually leads to right-sided heart failure and death within five to seven years of diagnosis. In fact,...
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Drug Loaded Nanoparticles Turn Fat Cells Brown to Help Control Obesity
Brown fat cells are much easier for the body to burn than regular white lipocytes. Obese people with a particularly high ratio of white to brown fat cells can have a hard time losing weight even when while dieting and exercising. Nanotechnology may soon help people turn white fat into brown fat, turning a daunting challenge...
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FDA approves new antibacterial drug
The U.S. Food and Drug Administration today approved Vabomere for adults with complicated urinary tract infections (cUTI), including a type of kidney infection, pyelonephritis, caused by specific bacteria. Vabomere is a drug containing meropenem, an antibacterial, and vaborbactam, which inhibits certain types of resistance mechanisms used by bacteria. “The FDA is committed to making new...
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Researchers review the clinical potential of senolytic drugs on aging
Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals. In a review article published online in the Journal of the American Geriatrics Society, Mayo Clinic aging experts say that, if proven to be effective and safe in humans, these drugs could be “transformative”...
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Non-psychotropic cannabinoids show promise for pain relief
Some cancers love bone. They thrive in its nutrient-rich environment while gnawing away at the very substrate that sustains them, all the while releasing inflammatory substances that cause pain—pain so severe that opioids often are prescribed to allay the agony. But opioids recently have been denounced for their addictive nature. This summer, the nation’s opioid...
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Liraglutide tied to reduced progression of diabetic kidney disease
Johannes F.E. Mann, M.D., from the Friedrich Alexander University of Erlangen in Germany, and colleagues reported the prespecified renal outcomes of a randomized controlled trial involving patients with type 2 diabetes receiving usual care who were assigned to liraglutide or placebo. A total of 9,340 patients were randomized and followed for a median of 3.84 years. The researchers found...
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Study: Drug may curb female infertility from cancer treatments
An existing drug may one day protect premenopausal women from life-altering infertility that commonly follows cancer treatments, according to a new study. Women who are treated for cancer with radiation or certain chemotherapy drugs are commonly rendered sterile. According to a 2006 study from Weill Cornell Medicine, nearly 40 percent of all female breast cancer survivors...