by University of California – San Diego Credit: Pixabay/CC0 Public Domain Approximately one-fourth of the general population worldwide has nonalcoholic fatty liver disease, known as NAFLD, an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. NAFLD can lead to cirrhosis, liver cancer and liver failure. In a...
Will Pass October 26, 2022 Cocaine, methamphetamine, opioids, and cannabis may independently increase risk of atrial fibrillation (AFib), based on data from almost 24 million people. While more work is needed to uncover causal links, physicians should be aware that these commonly abused substances could be driving new cases of AFib, reported investigators from the University of California,...
by Josh Barney, University of Virginia Overview of KSTAR algorithm. First, we heuristically prune dense and highly overlapping weighted kinase-substrate prediction graphs from NetworKIN into many sparse, binary graphs. Statistical enrichment is calculated for an experiment that has a defined set of phosphorylation sites for every kinase across all networks using a hypergeometric distribution. We...
RUHR-UNIVERSITY BOCHUM “This puts our understanding of the interaction between the thyroid gland and the heart on a new footing and might pave the way to personalised preventive care,” says associate professor Dr. Johannes Dietrich from the Department of Medicine at St Josef Hospital, Clinic of Ruhr University Bochum, Germany (RUB). The researchers published their...
by University of Eastern Finland Serum total TDP-43 concentrations in individual subgroups based on the clinical phenotypes of frontotemporal dementia (FTD), in the total FTD group including all of the phenotypes, and in healthy controls (HC). The values were obtained using natural logarithmic transformation. Black horizontal lines indicate group median and interquartile ranges. p-values are...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN For years, cardiologists have zeroed in on a hormone called BNP as a gold standard to determine if patients with heart failure are at risk of severe illness or death. It’s released by the heart in response to when the cardiac tissue stretches due to pressure. While the B-type natriuretic peptide,...
KAROLINSKA INSTITUTET Among patients with kidney cancer, the activity of four specific genes in the cancer cells seems to be able to predict the risk of the tumour spreading and the patient’s chances of survival. This is shown by researchers from Karolinska Institutet in Sweden in a preclinical study published in Nature Communications. “This could potentially...
DECODE GENETICS Scientists at deCODE genetics a subsidiary of Amgen report in Arthritis & Rheumatology that the level of cartilage acidic protein-1 (CRTAC1) in plasma is a potential biomarker of osteoarthritis (OA) through its association with OA risk and progression to joint replacement. The level of CRTAC1 in plasma was recently associated with osteoarthritis (OA)...
The CHILDhood Asthma Risk Tool (CHART) can identify children at high risk for asthma at as early as 3 years of age, according to a study published online Oct. 6 in JAMA Network Open. Myrtha E. Reyna, from the Hospital for Sick Children in Toronto, and colleagues developed and evaluated the use of a symptom-based screening...
by University of Plymouth Credit: CC0 Public Domain People with dementia are likely to have taken more than three medications for other health conditions in the five years directly before their diagnosis, according to new research. The study is the first to provide an in-depth exploration of the links between evolving polypharmacy—which involves a patient...
