CEDARS-SINAI MEDICAL CENTER Science has long shown that men are at greater risk for developing atrial fibrillation (AFib) than women; but it has never been fully understood why women would be protected from developing the condition. New research from the Smidt Heart Institute at Cedars-Sinai challenges this conventional wisdom by demonstrating that women—when height is accounted for—have...
Category: <span>Prognostic</span>
Post
Early onset of diabetes, hypertension can predict early glaucoma, ophthalmologists report
by UT Southwestern Medical Center Credit: Pixabay/CC0 Public Domain The earlier individuals develop type 2 diabetes or hypertension in life, the earlier they are likely to develop primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, researchers from UT Southwestern reported in a recent study. The findings, published in Clinical Ophthalmology, could lead to better screening...
Post
More accurate prediction of cancer risk in individuals with Li-Fraumeni syndrome
by Medizinische Hochschule Hannover Spectrum of TP53 germline variants and statistically significant genotype-phenotype correlations. Colored spheres refer to different patients harboring the corresponding variant. Note: Y103* is based on two different nucleotide substitutions; whole gene deletions include two gross deletions with differing breakpoints. The genotype–phenotype correlation was based on data from 94 families. CNV, Copy number...
Post
Glycoprotein GPNMB is a possible biomarker for Parkinson’s Disease risk
AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE (AAAS) Computational, cell biological, and human tissue-based studies establish GPNMB as a risk gene and potential therapeutic target for Parkinson’s Disease (PD), researchers report. PD is a debilitating progressive neurodegenerative brain disorder that affects millions of people worldwide. Diagnosis of the disease often relies on the presence of motor control...
Post
Early blood tests predict death, severe disability for traumatic brain injury
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN IMAGE: A GRAPHIC OF TBI WITH BLOOD TEST VIALS. CREDIT: JUSTINE ROSS, MICHIGAN MEDICINE A study finds that blood tests taken the day of a traumatic brain injury can predict which patients are likely to die or survive with severe disability, allowing clinicians to make decisions earlier on possible...
Post
Pathway uncovered for most significant lupus genetic risk factor
A study suggests that researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus. Systemic lupus erythematosus is a common, incurable autoimmune disease affecting millions worldwide, with a particularly high prevalence among women. A genetic variant, called HLA-DRB1*03:01, is the greatest risk factor...
Post
FIU researchers discover how DDT exposure contributes to Alzheimer’s disease risk
FLORIDA INTERNATIONAL UNIVERSITY VIDEO: JASON RICHARDSON, PROFESSOR AT FLORIDA INTERNATIONAL UNIVERSITY’S ROBERT STEMPEL COLLEGE OF PUBLIC HEALTH & SOCIAL WORK, DISCUSSES A NEW STUDY THAT REVEALS HOW DDT EXPOSURE CONTRIBUTES TO ALZHEIMER’S DISEASE RISK. CREDIT: FLORIDA INTERNATIONAL UNIVERSITY MIAMI (Aug. 17, 2022) – A new study led by researchers from Florida International University (FIU) reveals a...
Post
Inflammatory signaling linked to leukemia progression
by Kevin McCullough, Northwestern University Loss of IL-6 rescues multi-organ leukemia infiltrations in DKO mice. (A) Microarray gene expression data of bone marrow CD34+ cells from 47 MDS patients. Housekeeping genes GAPDH and ACTB were plotted to demonstrate the modest raw intensity without normalization. TNNT2 and CD34 were plotted as negative and positive controls, respectively. Data...
Post
New study indicates people with current cancer diagnosis may face severe complications from COVID-19
by Stephanie Winn, UC Davis Credit: Unsplash/CC0 Public Domain A new study has found that a current cancer diagnosis posed a significant risk for severe outcomes during the first two years of the COVID-19 pandemic, including ICU admission and death. UC Davis Comprehensive Cancer Center researchers took part in the study, which was published this...
Post
New understanding of how faulty metabolism triggers adrenal cancer
by Jeff Hansen, University of Alabama at Birmingham Credit: Priyanka Gupta et al, Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111218 Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands. This discovery explains how impaired metabolism due to mutations in a key enzyme called succinate dehydrogenase B disables a...