Antara Ghosh TOPLINE:A two-step screening, using a risk score and biomarkers, can identify patients with diabetes at a higher risk for heart failure who will most likely benefit from preventive drugs. METHODOLOGY:Researchers compared screening methods and downstream risk for heart failure in 5 years, particularly those without atherosclerotic cardiovascular disease (ASCVD).They pooled data from 4889...
Category: <span>Prognostic</span>
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Team discovers how to predict whether patients with leukemia will be sensitive to epigenetic drugs
by Josep Carreras Leukaemia Research Institute Credit: Cancer Research Communications (2024). DOI: 10.1158/2767-9764.CRC-23-0389Alterations in the chemical modifications that control gene expression, known as epigenetics, have proven to be one of the most characteristic properties of all human tumors. This realization has generated the development of intense pharmacological research to find drugs that act at this level...
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Black women with high blood pressure before age 35 may have triple the risk of a stroke
by American Heart Association Credit: Christina Morillo from PexelsBlack women who develop high blood pressure before age 35 and are on medication for hypertension may have triple the odds of having a stroke, and those who develop high blood pressure before age 45 may have twice the risk of suffering a stroke, according to a preliminary...
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Tiny particles offer big clues toward predicting Alzheimer’s decades in advance
by Translational Genomics Research Institute Credit: Pixabay/CC0 Public DomainIn a study published in the journal, Cells, a team of scientists describe using machine learning models to identify changes in RNA molecules of plasma extracellular vesicles (EVs) that may hold potential for identifying Alzheimer’s disease (AD) at its earliest stages. EVs are tiny particles released by the...
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Study: Women with alcohol-related liver disease have greater mortality risk than men with condition
by Cedars-Sinai Medical Center Credit: Pixabay/CC0 Public DomainInvestigators from the Smidt Heart Institute at Cedars-Sinai and colleagues found that women with fatty liver disease related to alcohol consumption have almost twice the risk of dying within a certain time period than men with the same condition. The findings, published in the Journal of Hepatology, highlight the...
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Novel approach identifies people at risk of developing TB
by University Hospitals of Leicester NHS Trust Baseline [18F]FDG-PET-CT and chest radiograph features of incipient tuberculosis. Credit: The Lancet Microbe (2024). DOI: 10.1016/S2666-5247(23)00289-6A novel approach to studying the progression of tuberculosis (TB) from infection to disease has identified and treated people at increased risk of developing the disease that current methods of testing would not.Researchers...
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Enlarged breast tissue in men linked to heightened risk of death
by British Medical Journal Credit: Unsplash/CC0 Public DomainMen with enlarged breast tissue, not caused by excess weight—a condition formally known as gynecomastia—may be at heightened risk of an early death before the age of 75, suggests the first study of its kind, published online in the open access journal BMJ Open. Those with a pre-existing risk...
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Study uncovers new biological marker for scleroderma
by Gillian Rutherford, University of Alberta PolySia expression is highest in the fibrotic skin of dSSc patients. Skin biopsy sections from the different groups were used for our experiments. Credit: Journal of Autoimmunity (2023). DOI: 10.1016/j.jaut.2023.103110A cross-disciplinary University of Alberta research team has uncovered a biological marker for scleroderma that can predict which patients will develop...
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Research suggests link between medical cannabis for chronic pain and abnormal heart rhythm
by European Society of Cardiology Credit: Unsplash/CC0 Public DomainPeople taking medical cannabis for chronic pain have a slightly increased risk of arrhythmia, according to research published in the European Heart Journal today (Thursday). Arrhythmia is when the heart beats too slowly, too quickly or irregularly. It includes conditions like atrial fibrillation. Recreational use of cannabis has...
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Severe MS predicted using machine learning
Peer-Reviewed Publication LINKÖPING UNIVERSITY MIKA GUSTAFSSON, PROFESSOR OF BIOINFORMATICS AT THE DEPARTMENT OF PHYSICS, CHEMISTRY AND BIOLOGY AT LINKÖPING UNIVERSITY, SWEDEN. CREDIT: THOR BALKHED/LINKÖPING UNIVERSITY A combination of only 11 proteins can predict long-term disability outcomes in multiple sclerosis (MS) for different individuals. The identified proteins could be used to tailor treatments to the individual...