by Medical University of South Carolina This figure depicts the two major T-cell co-stimulation pathways, ICOS and CD28, targeted by the new drug candidate ALPN-101 as compared to CTLA-4-Fc CD28/B7 pathway inhibitors (abatacept and belatacept) for the treatment of graft-versus-host disease. A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D.,...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – Elevated levels of a little-known lipoprotein in the blood that may put people at high risk of cardiovascular disease can be as accurately detected by genetic testing as by conventional laboratory measurement, researchers at Massachusetts General Hospital (MGH) have found. In a study published in JAMA Cardiology, the team reported that genetic risk...
by Bob Yirka , Medical Xpress A large team of researchers affiliated with a host of institutions across Japan has identified multiple loci associated with ancestry-specific risk factors for coronary artery disease. In their paper published in the journal Nature Genetics, the group describes their analysis of genetic information from several publicly available databases and its results. Coronary...
UNIVERSITY OF TAMPERE An international research team has discovered a principle that explains the metastasizing of prostate cancer. When cancer evolves within the prostate, multiple spatially intermixed cancer cell clones are created that may invade the organs surrounding the prostate. However, only one dominant cell clone spreads systemically in the body and creates metastases. In...
IMPACT JOURNALS LLC Volume 11, Issue 28 of Oncotarget features “Rapid onset type 1 diabetes with anti-PD-1 directed therapy“, by Yun et al. and reported that Type 1 diabetes is a rare immune-related adverse event caused by checkpoint inhibitors with serious risk for diabetic ketoacidosis. Of the patients who received immunotherapy, 5 patients were found to have type 1 diabetes,...
KING’S COLLEGE LONDON Patients of Black ethnicity have an increased risk of requiring hospital admission for COVID-19, while patients of Asian ethnicity have an increased risk of dying in hospital from COVID-19, compared to White patients, a study has found. Data analysis published today (Friday 9th October, 2020) in EClinicalMedicine, led by researchers at King’s College London, with...
by Joel Winston, Queen Mary, University of London Knee x-ray. New research by Queen Mary University of London and the University of Southampton’s Medical Research Council Lifecourse Epidemiology Unit (MRC LEU) has found associations between lower bone mineral density and worse cardiovascular health in both men and women. Published in the Journal of Bone and Mineral Research, the study used the internationally...
RMIT UNIVERSITY IMAGE: THE STUDY SHOWED THE SEVERITY OF SLEEP APNEA WAS LINKED WITH A CORRESPONDING BUILD-UP OF AMYLOID PLAQUES (SEEN HERE AS BROWN PATCHES IN THE BRAIN TISSUE). New research has confirmed long-suspected links between sleep apnea and Alzheimer’s disease, finding identical signs of brain damage in both conditions. While the cause of Alzheimer’s disease remains...
AMERICAN HEART ASSOCIATION DALLAS, Sept. 28, 2020 — A veteran’s study identified more than a dozen genes associated with abdominal aortic aneurysm (AAA) that could be used to better identify people at risk for the often-deadly condition, according to new research published today in the American Heart Association’s flagship journal Circulation. Abdominal aortic aneurysm is a bulging or...
THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS) CLEVELAND, Ohio (September 28, 2020)–Menopause is accompanied by numerous symptoms that can interfere with a woman’s quality of life, but can they also cause health problems? A new study suggests that they can, with an increased risk of cardiovascular disease in women who have two or more moderate to...
