VANDERBILT UNIVERSITY MEDICAL CENTER Even a minor surgery such as a laparoscopic gallbladder removal can prove to be a high-risk and even fatal procedure for frail patients, according to new research published in JAMA Surgery. A team of researchers from leading U.S. academic medical centers and VA medical centers examined the records of 432,828 patients...
Category: <span>Prognostic</span>
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Late stage breast cancer survival estimate is ‘rarely accurate’
Specialists warn that single number average survival estimates for advanced stage breast cancer are unhelpful and usually inaccurate. Instead, they advise doctors to provide several case-specific survival estimates to help people plan with realism and hope. Breast cancer is the form of cancer that affects women the most often — about 2.1 million Trusted Source...
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Cleveland Clinic develops calculator to estimate 10-year risk of diabetes complications
Personalized score can inform patients who are considering weight-loss surgery CLEVELAND CLINIC Tuesday, Nov. 5, 2019, CLEVELAND: Patients struggling with type 2 diabetes and obesity are faced with the decision of whether to receive usual medical care or undergo weight-loss surgery. Now, a new risk calculator developed by Cleveland Clinic researchers can show these patients...
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Accurate lymphoma prognosis from a simple blood test
by Kristin Samuelson, Northwestern University After a patient is diagnosed with lymphoma—an often-treatable type of cancer that attacks the lymph nodes, spleen, thymus, bone marrow and more—the natural next steps are determining the patient’s survival outlook and deciding the best course of treatment. But current methods of doing so remain inaccurate or invasive, often involving...
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Model learns how individual amino acids determine protein function
Technique could improve machine-learning tasks in protein design, drug testing, and other applications MASSACHUSETTS INSTITUTE OF TECHNOLOGY A machine-learning model from MIT researchers computationally breaks down how segments of amino acid chains determine a protein’s function, which could help researchers design and test new proteins for drug development or biological research. Proteins are linear chains of amino acids, connected by...
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Heart failure patients with a higher protein intake live longer
Heart failure patients who consume more protein live longer, according to research presented today at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology congress. Elderly adults need to maintain muscle mass for optimal health. However, most lose muscle mass as they age and are less efficient at using dietary protein to build muscle....
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Gene panel predicts course of cystic fibrosis
Researchers at National Jewish Health have identified 10 immune-related genes whose activity during a respiratory infection predict the long-term prognosis for cystic fibrosis patients better than conventional measures. Five years after being evaluated, patients in the lowest-risk group were all alive and doing well, whereas 90 percent of patients in the highest risk cluster...
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Gene therapy: What you need to know
British drugmaker GlaxoSmithKline made headlines last year when it won approval for its gene therapy Strimvelis in Europe. But, due to a small patient population and high price tag, the drug has only been used once. So far, despite higher levels of safety and efficacy than previous iterations, the new wave of gene therapies still...
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Serum cystatin C predicts mortality with cirrhotic ascites
(HealthDay)—Serum cystatin C level is an excellent predictor of mortality in patients with cirrhotic ascites, according to a study published online Sept. 14 in the Journal of Gastroenterology and Hepatology. Yeon Seok Seo, M.D., Ph.D., from the Korea University College of Medicine in Seoul, South Korea, and colleagues prospectively enrolled 350 patients with cirrhotic ascites (mean...
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Fasting blood glucose trajectory may predict future MI
(HealthDay)—For individuals without diabetes, certain fasting blood glucose (FBG) trajectories are associated with the risk of future myocardial infarction (MI), according to a study published online Sept. 8 in Diabetes Care. Cheng Jin, from the Kailuan General Hospital in Tangshan, China, and colleagues conducted a prospective cohort study involving 68,297 participants without diabetes free of MI, stroke, and cancer prior...