ARIZONA STATE UNIVERSITY IMAGE: LEFT TO RIGHT: PROFESSOR JULIAN CHEN AND HIS COLLABORATORS FROM THE SCHOOL OF MOLECULAR SCIENCES AT ARIZONA STATE UNIVERSITY, DHENUGEN LOGESWARAN AND KHADIZA AKHTER. CREDIT: MARY ZHU For the very first time, a study led by Julian Chen and his group in Arizona State University’s School of Molecular Sciences and the...
by Medical University of South Carolina Immunofluorescence images showing healthy (left) and scleroderma (right) lung. The scleroderma lung shows reduced levels of Cathepsin L (green) and increased levels of fibroblast activation marker (red). Image courtesy of Joe Mouawad, Medical University of South Carolina. Credit: Joe Mouawad, Medical University of South Carolina Much of the research...
UNIVERSITY OF ARIZONA IMAGE: YEAST WITH A RED FLUORESCENT PROTEIN MARKING THE VACUOLE – THE NUTRIENT STORAGE COMPARTMENT OF THE CELL – AND A GREEN FLUORESCENT PROTEIN MARKING AGGREGATES OF TORC1 THAT FORM IN CELLS MISSING AIT1. CREDIT: ANDREW CAPALDI AND TEAM Like bacteria, yeasts are found everywhere, even in and around our bodies. And,...
by University at Buffalo A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body (orange). Credit:...
Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design. In the new papers, biologists at the University of Washington School of Medicine show that machine learning can be used to create protein molecules much more accurately and quickly than previously possible. The scientists hope this...
SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI IMAGE: PRIONS CREDIT: NATIONAL INSTITUTE OF HEALTH: HTTPS://WWW.FLICKR.COM/PHOTOS/NIHGOV/48440889002/IN/PHOTOLIST-NDO19F-2GNYDDQ Prion diseases, such as bovine spongiform encephalopathy (‘mad cow disease’), are lethal neurodegenerative infectious diseases that affect humans and other mammals and for which there is currently no cure. These diseases are caused by the accumulation of prions, which are misfolded versions...
by King’s College London Illustration of the cardiac FunSel screening system. The system generates a pool of AAV9 vectors to inject into mice and transduce heart cells, which are sequenced to identify protective factors. Credit: G. Ruozi, et al., Science Translational Medicine (2022) Scientists working to develop new therapies and treatments for heart failure patients have discovered...
by Northwestern University Mitochondria. Credit: Wikipedia commons A change in function in a mitochondrial antioxidant protein increases stem cell gene expression that promotes the development of more aggressive cancerous cells, according to a recent Northwestern Medicine study published in Proceedings of the National Academy of Sciences. While the protein superoxide dismutase-2 (SOD2) has been known to...
by Massachusetts General Hospital Credit: Hajera Amatullah et al, Cell (2022). DOI: 10.1016/j.cell.2022.06.048 The structure of chromatin—the mixture of DNA and proteins that form chromosomes—can affect gene expression, and certain chromatin “readers” are important for monitoring this structure often in response to environmental cues. Mutations within one such reader, called Speckled Protein 140 (SP140), are associated with an...
Researchers track protein binding, build synthetic proteins to study gene expression. How does a nose remember that it’s a nose? Or an eye remember that it’s an eye? As scientists probe the question of how cells remember what kind of cells they are supposed to be, or their genetic lineage, it’s important to understand how...
