The finding could eventually lead to possible therapies for the especially dangerous melanoma and pancreatic adenocarcinoma, as well as the most common type of childhood brain cancer and adult skin cancer. The study appears in the journal Life Science Alliance. The discovery concerns the GLI1 protein, which is important in cell development but has also been found...
Category: <span>Proteomics</span>
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DeepMind found the structure of nearly every protein known to science
By Nicole Wetsman Jul 28, 2022, 7:00am EDT A protein structure identified by AlphaFold. Image: DeepMind DeepMind is releasing a free expanded database with its predictions of the structure of nearly every protein known to science, the company, a subsidiary of Google parent Alphabet, announced today. DeepMind transformed science in 2020 with its AlphaFold AI software, which produces highly accurate...
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Intervening to stop bone loss
by Katherine Unger Baillie, University of Pennsylvania Shuying (Sheri) Yang. Credit: University of Pennsylvania Bone remodeling in the body involves a balancing act between osteoblasts, cells that build bone, and osteoclasts, cells that break it down. Diseases such as osteoporosis, arthritis, and periodontitis involve bone loss, and are linked with an overabundance of osteoclast activity....
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How the intestine replaces and repairs itself
Lymphatic system found to coordinate intestinal regeneration. To act as a robust barrier against pathogens while also absorbing needed nutrients, the lining of the intestines must regenerate on a daily basis to remain equal to the task. The intestine’s resident stem cells are responsible for meeting this need for constant repair and replenishment, but each stem...
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A new treatment approach for cystic fibrosis
by Cold Spring Harbor Laboratory Identification of NMD-inhibiting ASOs and assessment of their specificity. a Schematic of NMD reporters. The numbers show the CFTR exons in the NMD reporters. The red asterisk (*) indicates the location of the W1282X mutation. b Schematic of ASO screening. 19 MOE-PS-modified 15-mer ASOs (yellow and magenta bars) were designed to cover the presumptive EJC binding sites...
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Diabetes: A step closer to a life without insulin
by University of Geneva S100A9 suppresses diabetic ketogenesis via hepatic TLR4. A Scheme indicating the generation of RIP-DTR;Tlr4WT (n = 5), RIP-DTR;Tlr4WT; S100A9OE (n = 6), RIP-DTR;Tlr4KO; S100A9OE (n = 7) and RIP-DTR;Tlr4Liver; S100A9OE (n = 6) experimental groups. Adenoviral injections and HTVI were done 3 days before or the same day of the first DT injection, respectively. B Plasma insulin levels of mice at day 0...
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New protein complex structure reveals possible ways to target key cancer pathway
by Alex Viveros, Broad Institute of MIT and Harvard The SHOC2-MRAS-PP1C complex is made up of three proteins that regulate the RAS signaling pathway and help cancer cells with RAS mutations survive. Credit: Broad Institute and Dana-Farber Cancer Institute Some of the most infamous drivers of cancer are mutations in RAS genes, which lead to tumor...
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Study results challenge current thinking about autosomal dominant polycystic kidney disease
AMERICAN SOCIETY OF NEPHROLOGY Highlight New research indicates that the polycystin-2 protein in cells’ endoplasmic reticulum is important for maintaining kidney health, and its lack can contribute to autosomal dominant polycystic kidney disease. Washington, DC (July 12, 2022) — Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic condition that can lead to kidney failure...
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New structure found in cells
Every cell contains millions of protein molecules. Some of them have the ability to phase-separate to form non-membrane-bound compartments, called biomolecular condensates, inside a cell. It has long been assumed that there was no further structure underlying these condensates, only solution-soluble proteins. A research group led by Rohit Pappu, the Gene K. Beare Distinguished Professor of biomedical...
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Targeting a human protein to squash SARS-CoV-2, other viruses
by American Chemical Society Apratoxin S4 (structure shown here) is effective against SARS-CoV-2 in human cells and could be a pan-viral therapeutic. Credit: Adapted from ACS Infectious Diseases 2022, DOI: 10.1021/acsinfecdis.2c00008 More than two years into the COVID-19 pandemic, people are realizing that the “new normal” will probably involve learning to co-exist with SARS-CoV-2. Some treatments are available,...