by CU Anschutz Medical Campus Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Currently, there are no disease modifying therapies for Parkinson’s disease that can change the progression of the disease. An international team of scientists led by faculty at the University of...
INSTITUTE OF CANCER RESEARCH Key protein identified that helps turn pancreatic cancer cells into more aggressive form Pattern of cells in pancreatic tumours follows mathematical law first proposed by Alan Turing Fundamental discovery could pave way for new pancreatic cancer treatments Scientists have shown it is possible to reverse a key process that allows pancreatic...
KAROLINSKA INSTITUTET Researchers at Karolinska Institutet and SciLifeLab in Sweden describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function. Their innovative technique can lead to improved drugs for diseases involving oxidative stress, such as cancer, Alzheimer’s disease and lung...
Cold Spring Harbor Laboratory (CSHL) Professor Hiro Furukawa takes an architectural approach to brain research. He creates structural 3D maps of important proteins that malfunction in brain disorders. Furukawa has zeroed in on a protein called the NMDA (for N-methyl-D-aspartate) receptor that plays a key role in learning and memory. The NMDA receptor acts as a channel to allow ions into neurons...
by Brigham and Women’s Hospital A graphic depicts the “two faces of alpha-synuclein” and the transition from normal states (upper, organized molecular machines on a well-defined grid) to pathologic states in which there is membrane disruption, altered protein interactions and localization (lower, chaotic, disrupted machines, darker tone). Credit: Gergana Petrova. One of the hallmarks of...
UNIVERSITY OF SOUTHERN CALIFORNIA IMAGE: ARTIST’S RENDERING OF GABA TRANSPORTER 1 (GAT-1) EMBEDDED IN A NEURON’S MEMBRANE. TIAGABINE (GREEN) BLOCKS GAT-1 FROM SHUTTLING THE NEUROTRANSMITTER GABA (YELLOW AND RED) INTO THE CELL FROM THE SYNAPSE. (ILLUSTRATION: YEKATERINA KADYSHEVSKAYA.) CREDIT: USC DORNSIFE/YEKATERINA KADYSHEVSKAYA In brief: Scientists have, for the first time, determined the structure of a...
By Nick Lavars June 08, 2022 Research into alcohol use disorder has implicated a new protein in the anxiety associated with withdrawal Depositphotos Alcohol use disorder is a leading cause of preventable death and a complex disease, but by understanding its effects on brain function scientists hope to lower the risk and rates of relapse. The latest...
UNIVERSITY OF MICHIGAN Scientists have identified a new role for a protein complex at the center of a human genetic disorder called Bardet-Biedl syndrome, or BBS, for which there is currently no cure. Bardet-Biedl syndrome arises when the BBSome protein complex malfunctions. Because the BBSome regulates the form and function of cilia, the hair-like structures...
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE When something goes wrong in mitochondria, the tiny organelles that power cells, it can cause a bewildering variety of symptoms such as poor growth, fatigue and weakness, seizures, developmental and cognitive disabilities, and vision problems. The culprit could be a defect in any of the 1,300 or so proteins that...
by Bob Yirka, Medical Xpress Vimentin is overexpressed in tumor endothelial cells and is present extracellularly. a, b Vimentin mRNA (a; n = 3; qPCR) and protein (b; n = 4; flow cytometry) expression in isolated endothelial cells (EC) from human colon tumor (TEC) and normal colon (NEC). c Vimentin mRNA expression in isolated EC from human (colon, n = 13;...
