UNIVERSITY OF BARCELONA The RNF41 protein could be a new therapeutic target in the fight against two chronic liver diseases: cirrhosis and liver inflammation. This is stated in a study published in the journal Science Translational Medicine led by researcher Pedro Melgar-Lesmes, from the Department of Biomedicine at the Faculty of Medicine and Health Sciences of the...
Category: <span>Proteomics</span>
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Tau-regulating protein identified as a promising target for developing Alzheimer’s disease treatment
by Perelman School of Medicine at the University of Pennsylvania Individuals with Alzheimer’s disease (AD) have increased neurofibrillary tangles (NFTs) of tau proteins but reduced TRIM11, as shown in the bottom two quadrants, compared to individuals without AD, shown in the top two quadrants. Credit: Penn Medicine A gene encoding a protein linked to tau production—tripartite...
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Scientists Discover RELMalpha Protein Protects Females Against Obesity
By UNIVERSITY OF CALIFORNIA, RIVERSIDE JULY 26, 2023 Scientists have conducted a study using a mouse model to understand sex differences in obesity. They found that female mice, compared to males, are more resistant to obesity and inflammation due to a higher secretion of an immune protein called RELMalpha. The study reveals a crucial ‘RELMalpha–eosinophil–macrophage axis’ in...
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Researchers solve structure of immune-evading HIV protein complex
by Okinawa Institute of Science and Technology When encapsidated in budding HIV-1 virions, APOBEC3G (A3G) suppresses viral amplification by modifying the viral genome after reverse transcription in infected cells (left). But HIV-1 Vif catalyzes degradation of A3G, leading to infectious virions (right). Credit: OIST The HIV-1 virus can neutralize cellular defenses with its viral infectivity factor...
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A new mechanism may lead to new treatment options of chronic kidney diseases
Peer-Reviewed Publication AARHUS UNIVERSITY IMAGE: “WE HAVE DISCOVERED THAT A PROTEIN CALLED PCSK9, WHICH INFLUENCES THE CHOLESTEROL LEVELS IN THE BLOOD AND INCREASES THE RISK OF CARDIOVASCULAR DISEASES, ALSO HAS COMPLETELY NEW AND UNEXPECTED EFFECTS IN THE KIDNEYS. THIS KNOWLEDGE CAN POTENTIALLY BE USED TO TREAT PATIENTS WHOSE KIDNEYS ARE OVERLOADED AND THEREFORE HAVE AN...
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Reduced levels of FKBP5 promote atrial fibrillation
BAYLOR COLLEGE OF MEDICINE Atrial fibrillation (AFib) is the most common type of heart arrhythmia. This serious condition occurs when the heart beats so fast that the upper chambers of the heart quiver. This irregular heartbeat can lead to severe conditions, including heart failure, dementia and a fivefold increase in the risk of stroke. AFib affects...
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Scientists discovered a possible treatment for baldness from hairy moles and it can be injected like Botox
Scientists are looking at molecules in mole hair as a potential treatment for baldness. Laura Herrera/Stocksy Researchers say molecules found in mole hair may be a key to developing a new Botox-like treatment for baldness. They say the new treatment, if it proves successful, could be a major advancement in the field. Experts agree but note...
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Engineered approach to remove protein aggregates from cells
UNIVERSITY OF GOTHENBURG IMAGE: ARTHUR FISCHBACH AND THOMAS NYSTRÖM, SAHLGRENSKA ACADEMY AT THE UNIVERSITY OF GOTHENBURG. CREDIT: PHOTO BY UNIVERSITY OF GOTHENBURG. Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer’s, Parkinson’s or Huntington’s disease. A new study by the Nyström lab at Gothenburg University, in collaboration with the Max Planck...
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Researchers reveal mechanism of protection against breast and ovarian cancer
THE FRANCIS CRICK INSTITUTE In a new paper published today in Nature, researchers at the Francis Crick Institute have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer. Every time a cell replicates, mistakes can happen in the form of mutations, but specialised proteins exist to repair...
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Neuron Support Squad: Perlecan Protein Key to Synaptic Durability
Summary: A new study discovered the critical role that Perlecan, a protein, plays in maintaining the structural integrity of neurons, particularly the long branches called axons. The study found that in the absence of Perlecan, axons in Drosophila fruit flies broke apart during development, leading to the death of their connections or synapses. Perlecan aids in...