INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA IMAGE: IMMUNOFLUORESCENCE STAINING OF IL-17(WHITE) IN AGED MOUSE SKIN CREDIT: IRB BARCELONA A team of researchers from IRB Barcelona and CNAG identifies the IL-17 protein as a determining factor in skin ageing. Blocking the function of IL-17 reduces the pro-inflammatory state and delays the appearance of age-related features...
by Kate McAlpine, University of Michigan The new computer model, NeCLAS, predicts that a nanoparticle, shown as a set of yellow balls attached by netting, fits neatly around a very specific protrusion on a protein, marked in blue. The binding site is confirmed by experiments. These kinds of nanoparticles, called molecular tweezers, can be used to...
Peer-Reviewed Publication CHIBA UNIVERSITY IMAGE: RESEARCHERS USED MURINE AND HUMAN CD4+ T CELL LINES TO STUDY THE INFLUENCE OF METHOTREXATE ON TAP63 EXPRESSION CREDIT: AKIRA SUTO FROM CHIBA UNIVERSITY Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The clinical outcomes of patients with active RA can be improved using anti-rheumatic medications, such...
by Laurie Fickman, University of Houston Graphical abstract. Credit: JCI Insight (2023). DOI: 10.1172/jci.insight.164768 A team of researchers at the University of Houston College of Pharmacy is reporting that by manipulating TAK1, a signaling protein that plays an important role in development of the immune system, they can slow down disease progression and improve muscle function in Duchenne muscular dystrophy...
By WASHINGTON STATE UNIVERSITY MAY 22, 2023 New research indicates that lifespan in warm climates is not just passively shortened due to increased metabolic rate but is also actively regulated by a nervous system protein called NPR-8, which controls collagen expression. They found that worms lacking this protein had increased collagen expression in warmer temperatures, thereby exhibiting increased stress...
A molecular machine, which plays an essential ‘cargo’ role in controlling the delivery of proteins to the surface of human cells, and is implicated in several diseases, has been identified in a landmark study using artificial intelligence (AI). The research, led by an international team of scientists, is published in Cell. Researchers at the Universities of...
Researchers at the University of Toronto have developed an artificial intelligence system that can create proteins not found in nature using generative diffusion – the same technology behind popular AI image-creation platforms such as Midjourney and OpenAI’s DALL-E. The system will help advance the field of generative biology, which promises to speed up drug development by making the design and testing of entirely...
UNIVERSITY OF BIRMINGHAM Proteins that act like air traffic controllers, managing the flow of signals in and out of human cells, have been observed for the first time with unprecedented detail using advanced microscopy techniques. Described in new research published today in Cell, an international team of researchers led by Professor Davide Calebiro from the University of Birmingham has...
UNIVERSITY OF MISSOURI-COLUMBIA IMAGE: VIRUS IMAGE CREDIT: UNIVERSITY OF MISSOURI COLUMBIA, Mo. — While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection — a discovery...
CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER IMAGE: RESEARCHERS SHOWED THAT SYSTEMIC DELIVERY OF MYMK+MYMG-LV-DYS RESULTED IN A SIGNIFICANT LEVEL OF DYS+ MYOFIBERS. IMPORTANTLY, THE TEAM DID NOT DETECT EVIDENCE OF VIRAL TRANSDUCTION IN NON-SKELETAL MUSCLE TISSUES INCLUDING HEART, KIDNEY, LIVER, AND SPLEEN. DYSTROPHIC MICE EXHIBITED HEALTHIER MUSCLES (REDUCTIONS IN MUSCLES CELLS WHERE A DYE WAS ABLE...
