Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints, a study from Karolinska Institutet published in the scientific journal PNAS reports. The researchers hope that the results will give rise to new drugs for rheumatoid arthritis. In protecting...
Category: <span>Proteomics</span>
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Researchers identify new therapeutic target for colorectal cancer
ROCKEFELLER UNIVERSITY PRESS Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein called Importin-11 transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells, where it...
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Mutant proteins linked to DNA damage, muscular dystrophy
New Cornell-led research has found a strong connection between DNA damage triggered by mutations in proteins that surround the cell nucleus, known as lamins, and muscular dystrophy. By exploring the mechanisms that cause the damage, the researchers are hopeful their discovery can help shape better treatments. The team’s paper, “Mutant Lamins Cause Nuclear Envelope Rupture...
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Heart attack discovery could give hope to people not able to be treated
New treatment for heart attack scar UNIVERSITY OF SYDNEY Heart disease remains the largest killer in Australia and around the world. A new study has shown that a protein therapy- recombinant human platelet-derived growth factor-AB (rhPDGF-AB) – could improve outcomes following heart attack. After a heart attack, scar tissue forms and this negatively affects heart...
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Heart attack: New protein therapy may improve recovery
New preclinical research in animal models finds that infusing a specific protein into scar tissue after a heart attack improves and speeds up the recovery of the heart. Researchers are soon to test a new therapy for improving heart function and recovery after a heart attack. According to the American Heart Association (AHA), around 605,000...
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Targeting stem cells that drive aggressive blood cancer
by Peter MacCallum Cancer Centre Peter Mac scientists have found a way to target acute myeloid leukemia (AML) at its source—a discovery that could yield a more effective treatment for this aggressive and often incurable blood cancer. Prof Mark Dawson and Dr. Laura MacPherson led the international research team, in collaboration with researchers in Europe...
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Modifier gene may explain why some with cystic fibrosis are less prone to infection
UNIVERSITY OF CALIFORNIA – SAN DIEGO Cystic fibrosis is caused by an inherited mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Due to this mutation, the CFTR protein doesn’t embed in cell membranes to form a channel for chlorine ions the way it should. As a result, mucus-producing cells secrete a thicker-than-normal mucus...
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LSU Health discovers role of 2 proteins in sight and preventing blinding eye diseases
LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER New Orleans, LA – Research led by Nicolas Bazan, MD, Ph.D., Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, has discovered unique patterns of genetic activity that may lead to the development of blinding retinal diseases. The results are...
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The secret to a long life? For worms, a cellular recycling protein is key
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE LA JOLLA, CALIF. – December 11, 2019 – Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that worms live longer lives if they produce excess levels of a protein, p62, which recognizes toxic cell proteins that are tagged for destruction. The discovery, published in Nature Communications, could...
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Identification of a key protein linked to ageing
by Pasteur Institute Ageing is a dramatic public health issue in the face of the current demographic changes: the proportion of 60 and over in the world’s population will almost double by 2050. In this context, a new discovery has just broadened scientific knowledge. Researchers from the Developmental and Stem Cell Biology Department at the...