UNIVERSITY OF CALIFORNIA – SAN DIEGO Although the number of women being diagnosed and dying of ovarian cancer is declining, recurrence, drug resistance and mortality remain high for women with high-grade serous ovarian carcinoma, the most common form of epithelial ovarian cancer. A new study in the journal eLife by University of California San Diego School...
Category: <span>Proteomics</span>
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Parkinson’s disease may originate in the intestines
by Mette Louise Ohana, Aarhus University In 2003, a German neuropathologist proposed that Parkinson’s disease, which attacks the brain, actually might originate from the gut of the patients. Researchers from Aarhus have now delivered decisive supportive evidence after seeing the disease migrate from the gut to the brain and heart of laboratory rats. The scientific...
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Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease
Publication in Nature Communications HEINRICH-HEINE UNIVERSITY DUESSELDORF Proteins are central components of living material. These complex molecules made up of combinations of individual amino acids in some cases comprise thousands of individual atoms and have sophisticated three dimensional shapes. The term ‘fold’ is used to describe this structure. The fold of a protein determines its biological function. ...
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Could targeting variants of this gene help fight Alzheimer’s disease?
By Catharine Paddock PhD Fact checked by Carolyn Robertson Scientists have identified gene variants that appear able to alter the risk of Alzheimer’s disease by changing levels of a protein that is present in cerebrospinal fluid. In a recent Science Translational Medicinepaper, the international team describes how variants in the MS4A4A gene influence the risk...
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Patterns in DNA reveal hundreds of unknown protein pairings
Posted Today Sequencing a genome is getting cheaper, but making sense of the resulting data remains hard. Researchers have now found a new way to extract useful information out of sequenced DNA. By cataloging subtle evolutionary signatures shared between pairs of genes in bacteria, the team was able to discover hundreds of previously unknown protein interactions. This method...
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Scientists design protein blockers to fight obesity and heart disease
by Milady Nazir, University of Texas at San Antonio Almost four in 10 adult Americans are obese, according to the U.S. Centers for Disease Control and Prevention. What’s more alarming is that in the past two decades alone, in states such as Texas, the share of obesity among residents has tripled. If left unchecked, obesity can even lead to more serious problems...
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A new target for the treatment of idiopathic pulmonary fibrosis
by Experimental Biology and Medicine An article published in Experimental Biology and Medicine identifies a new target for the treatment of idiopathicpulmonary fibrosis. The study, led by Dr. Huaping Dai in the Department of Pulmonary and Critical Care Medicine and the Center of Respiratory Medicine at China-Japan Friendship Hospital and the National Clinical Research Center for Respiratory Disease in Beijing, China, reports that interleukin-25, an inflammatory...
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One step closer to chronic pain relief
Posted Today While effective drugs against chronic pain are not just around the corner, researchers from Aarhus University have succeeded in identifying a protein as a future potential target for medicinal drugs. Basic research shows that blocking a protein named sortilin prevents pain – initially in laboratory mice. Chronic pain can occur all over the body, and the patients have in...
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The activity of disease allele-selective zinc finger proteins in preclinical models of Huntington’s disease
by Sangamo Therapeutics, Inc. Sangamo Therapeutics, Inc., a genomic medicine company, today announced the publication of a manuscript describing the activity of allele-selective zinc finger protein transcription-factors (ZFP-TFs) in preclinical models of Huntington’s disease (HD). The data were published online on July 1 and will appear in the July 2019 issue of Nature Medicine. The...
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Scientists map elusive toxic proteins linked to Alzheimer’s, providing new molecular clues for prevention
A team of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer’s disease, allowing them to better understand what is happening deep within the brain during the earliest stages of the disease. The findings, published on the front cover of the current edition of the Royal Society of Chemistry flagship journal Chemical Science, provide new insights...