by National Institutes of Health Two proteins that bind to stress hormones work together to maintain a healthy heart in mice, according to scientists at the National Institutes of Health and their collaborators. These proteins, stress hormone receptors known as the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), act in concert to help support heart...
Category: <span>Proteomics</span>
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Discovery of a host mRNA that inhibits immune functions of antiviral protein RIG-I
by Kanazawa University Hepatitis C virus (HCV) is a hepatotropic virus, with about 80 million chronic infections confirmed worldwide. HCV infection leads to the development of chronic hepatitis, cirrhosis, and in some instances, hepatocellular carcinoma. The recent development of highly potent direct-acting antiviral drugs (DAAs), targeting viral proteins, facilitates virus elimination in >90 percent of treated individuals. However,...
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Biochemical switches identified that could be triggered to treat muscle, brain disorders
ST. JUDE CHILDREN’S RESEARCH HOSPITAL St. Jude Children’s Research Hospital scientists have found that the enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells. Such buildup is central to the pathology of three related diseases: inclusion body myopathy...
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Blocking protein’s activity restores cognition in old mice, study shows
by Stanford University Medical Center By blocking a protein’s activity with antibodies, Stanford University School of Medicine investigators were able to improve cognitive behavior in aging mice. A paper describing the finding will be published online April 3 in Nature. Tony Wyss-Coray, Ph.D., professor of neurology and neurological sciences, is the senior author. The lead author...
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How wrinkles could be a thing of the past: Scientists create drugs which could keep the skin youthful by boosting levels of a crucial protein
Scientists from the University of Colorado did research on mice and in the lab They said rubbing certain chemicals into the skin could help it regenerate These boost levels of an elastic protein which dwindles over time By COLIN FERNANDEZ SCIENCE CORRESPONDENT FOR THE DAILY MAIL PUBLISHED: 13:00 EDT, 3 April 2019 | UPDATED: 13:29 EDT, 3 April 2019 Saggy, wrinkled faces could soon be a thing of the past as researchers have identified...
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Neutrons paint atomic portrait of prototypical cell signaling enzyme
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis. The discovery was made by an international team of researchers using macromolecular neutron crystallography at the Department of...
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How nerve cells control misfolded proteins
RUHR-UNIVERSITY BOCHUM Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell and directs them towards disposal. In collaboration with the neurology department at the Ruhr-Ubiversität’s St. Josef-Hospital as well as colleagues at the Max Planck Institute of Biochemistry in Martinsried, an interdisciplinary team under the...
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UTSW researchers identify new mechanism to reduce inflammation
CREDIT: UT SOUTHWESTERN DALLAS – March 21, 2019 – UT Southwestern researchers have identified two proteins that act as gatekeepers to dampen a potentially life-threatening immune response to chronic infection. IMAGE: DR. ZIXU LIU view more CREDIT: UT SOUTHWESTERN The proteins – the transcription factors SIX1 and SIX2 – activate cellular pathways required for fetal development and later switch to...
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A billion years of evolution suggests a new approach for Alzheimer’s disease treatment
by Royal Holloway, University of London Credit: CC0 Public Domain New research by academics at Royal Holloway, University of London, urges scientists that are looking to finding a cure for Alzheimer’s disease to focus on the role of proteins in the brain that cause Alzheimer’s disease. This change in focus could enable the development of new treatments. It...
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Researchers discover new contributor to age-related hearing loss
Postdoctoral researcher Ting-Ting Du, left, led the research in the lab of Neuroscientist Jung-Bum Shin, right, that explores the role of the inner ear’s cuticular plate in hearing loss. Researchers at the University of Virginia School of Medicine have discovered a new potential contributor to age-related hearing loss, a finding that could eventually help doctors...