by Melissa Pappas, University of Pennsylvania Preparation and application of ligand-tethered lipidoid nanoparticles for targeted siRNA delivery to HSCs to treat liver fibrosis. a Formulation of AA-T3A-C12/siHSP47 LNP via microfluidic mixing. The ethanol lipid solution containing anisamide-tethered lipidoid (AA-T3A-C12), phospholipid (DSPC), PEG-lipid (C14-PEG), and cholesterol is rapidly mixed with an acidic aqueous solution containing HSP47 siRNA in a...
KTH, ROYAL INSTITUTE OF TECHNOLOGY IMAGE: THE YELLOW BAR IN THIS READOUT OF PROTEIN GFAP INDICATES ELEVATED EXPRESSION IN THE BLOOD OF PATIENTS WITH BRAIN TUMORS. (IMAGE: HUMAN DISEASE BLOOD ATLAS) CREDIT: HUMAN DISEASE BLOOD ATLAS Cancer prediction medicine gained a boost with the recent unveiling of a new cancer protein profile database compiled from...
KECK SCHOOL OF MEDICINE OF USC IMAGE: PICTURED IS AN ARTIST’S RENDERING OF CIRCADIAN CLOCK PROTEINS BMAL1 AND CLOCK INFLUENCING HEPATOCELLULAR CARCINOMA (HCC) CELL PROLIFERATION. THE STUDY SHOWS THAT IN HUMANS, HCC CELLS RELY ON BMAL1 AND CLOCK FOR SUSTAINED CELL GROWTH. TARGETING CLOCK PROTEINS PROVIDES A NEW PATHWAY TO DEVELOP NOVEL CANCER THERAPIES. CREDIT:...
WEILL CORNELL MEDICINE IMAGE: IMAGE OF HUMAN BREAST CANCER CELLS SHOWING A) IMMUNOSUPPRESSIVE MACROPHAGES NEAR TUMOR CONNECTIVE TISSUE, AND B) IMMUNOSTIMULATORY MACROPHAGES NEAR TUMOR NESTS. CREDIT: NIR BEN CHETRIT. A new method can illuminate the identities and activities of cells throughout an organ or a tumor at unprecedented resolution, according to a study co-led by researchers at...
MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — As cells perform their everyday functions, they turn on a variety of genes and cellular pathways. MIT engineers have now coaxed cells to inscribe the history of these events in a long protein chain that can be imaged using a light microscope. Cells programmed to produce these chains...
by Trinity College Dublin Human cells expressing inflammatory cytokines (stained green). Credit: Professor Martin Laboratory; Trinity College Dublin Scientists from Trinity College Dublin have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed to calm down the immune response actually does the...
by The Scripps Research Institute In postmenopausal women, depletion of estrogen causes excessive elevation of nitric oxide (NO) in the brain and thus generates S-nitrosylated complement factor C3 (SNO-C3). SNO-C3 triggers activated microglial cells, the innate immune cells in the brain, to phagocytose (or ‘eat’) neuronal synapses—the connections that mediate signaling between nerve cells in...
SINGHEALTH Singapore, 14 December 2022 — A new study has shown that restoring the balance of a protein in blood may be a promising treatment option for systemic lupus erythematosus, or lupus, an incurable autoimmune disease. The protein, CXCL5, helps to regulate the immune system through neutrophils, a type of white blood cell. In patients with...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: JAMES GILLRAY’S 1799 PAINTING ILLUSTRATES THE PAINFUL SYMPTOMS OF GOUT. CREDIT: WELLCOME LIBRARY, LONDON / HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/ Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin...
By Rich Haridy December 11, 2022 New research has uncovered a key immune mechanism that is responsible for the thickening of airway muscle associated with chronic asthma Depositphotos New research from the La Jolla Institute for Immunology has brought a novel, long-term treatment for severe asthma a step closer. Building on a decade of work,...
