by Pohang University of Science and Technology Cryo-EM analysis of designed de novo protein nanocages. Credit: POSTECH Researchers have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI). Their pioneering research was published in Nature on December 18. Viruses are uniquely designed to encapsulate genetic material within spherical protein shells, enabling them to replicate and...
Category: <span>Research Updates</span>
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Cooling sunscreen reflects both UV rays and solar heat
By Ben Coxworth December 23, 2024 The experimental sunscreen reportedly keeps users’ skin up to a total of 6.1 ºC (11 ºF) cooler than existing commercial sunscreens (pictured) Depositphotos View 2 Images Although sunscreen does help protect our skin from the sun’s harmful UV rays, it isn’t designed to keep that skin cool. An experimental new...
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Novel biomarker catches aging cells in the act
by Justin Jackson , Medical Xpress RNAscope of p16ink4a (green), Il23r (red), and Cd3e (cyan) from young (top, 2 mo.) and old (bottom, 24 mo.) kidney tissue from mice on p16-InkAttac background. DAPI nuclear stain is depicted in dark blue. Old kidney exhibits dense and perivascular Cd3e + Il23r+ immune nodes. Credit: Nature Aging (2024). DOI: 10.1038/s43587-024-00752-7 Mayo Clinic...
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A public health emergency is waiting at the bottom of the antibiotic resistance cliff
by Heidi Toth, Northern Arizona University Time course of emergence and prevalence of ST131-H30R and a hypothetical pan-resistant Escherichia coli strain. Credit: Communications Medicine (2024). DOI: 10.1038/s43856-024-00693-7 The rise of antibiotic-resistant bacteria could lead to a catastrophic rise in infection-related deaths, according to new research led by Northern Arizona University. The question likely isn’t whether it will happen,...
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Monitoring long-term cardiac activity with contactless radio frequency signals
by Chen Yehong, University of Science and Technology of China Overview of the proposed system. a Our system takes the RF signals reflected from the chest as input and outputs the real-time inter-beat interval (RT-IBI), which is then utilized to identify heart disease. b Schematic exploded-view of the RF device used in this paper. c Our...
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Skin Stress Biomarker May Predict Nerve Damage in Early T2D
Edited by Manasi Talwadekar December 09, 2024 076 Added to Email Alert TOPLINE: Increased cutaneous carbonyl stress is linked to slower nerve conduction in patients with metabolically well-controlled, recent-onset type 2 diabetes (T2D) and can predict the development of neuropathic deficits over 5 years. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Prospective analyses revealed some predictive value of...
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New genetic mutation found to suppress cancer growth
by UT Southwestern Medical Center Mice with the citation (cit) allele of H2-Aa strongly inhibited melanoma growth. Credit: Journal of Experimental Medicine (2024). DOI: 10.1084/jem.20240797 UT Southwestern Medical Center researchers have identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system. Their findings, published in the Journal of Experimental Medicine,...
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New molecule-creation method a ‘powerful tool’ to accelerate drug synthesis and discovery
Posted Today A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to creating complex, three-dimensional molecules. This innovation could help accelerate drug...
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Hidradenitis Suppurativa Linked to Inflammatory Eye Disease
Doug Brunk November 08, 2024 065 Added to Email Alert Nearly a quarter of patients with hidradenitis suppurativa (HS) experienced concomitant eye disease, and among those who did, nearly one third had a partial response with treatment, results from a systematic review showed.Hibo Rijal “Inflammatory and autoimmune comorbidities have been documented in HS, but the...
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Bijuva side effects: What you should know
Bijuva (estradiol/progesterone) is a brand-name capsule that’s prescribed for treating certain menopausal symptoms. As with other drugs, Bijuva can cause side effects, such as cardiovascular and vision problems. Bijuva has boxed warnings. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section later....