Peer-Reviewed Publication International Society for Stem Cell Research image: The technique for inducing differentiation of human motor neurons used in this paper clearly shows neuronal electrical activity.view more Credit: Satoru Morimoto Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years. In ALS, certain types of neurons called motor...
Category: <span>Research Updates</span>
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Brief outpatient rehabilitation program for post–COVID-19 condition
JAMA Network OpenPeer-Reviewed Publication JAMA Network About The Study: In this randomized clinical trial that compared a brief outpatient rehabilitation program with a cognitive and behavioral approach with usual care in 314 patients with post–COVID-19 condition, self-reported physical function improved statistically and clinically significantly in the intervention group after 2 to 8 outpatient encounters. The effect...
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Leveraging AI to assist clinicians with physical exams
by Mass General Brigham Credit: Pixabay/CC0 Public Domain Physical examinations are important diagnostic tools that can reveal critical insights into a patient’s health, but complex conditions may be overlooked if a clinician lacks specialized training in that area. While previous research has investigated using large language models (LLMs) as tools to aid in providing diagnoses, their...
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Chronic gut infection could play a role in Alzheimer’s development
by Arizona State University The brain’s immune cells, or microglia (light blue/purple) are shown interacting with amyloid plaques (red) — harmful protein clumps linked to Alzheimer’s disease. The illustration highlights the microglia’s role in monitoring brain health and clearing debris. Credit: Jason Drees/Arizona State University Arizona State University and Banner Alzheimer’s Institute researchers, along with their...
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Detroit cancer center unveils new device for treating liver cancer at home
by Julia Cardi Credit: Unsplash/CC0 Public Domain A new device is now available for treating advanced liver cancer at home using electromagnetic waves, the Barbara Ann Karmanos Cancer Institute announced. Called the “TheraBionic P1,” the device works via a small spoon-shaped antenna the patient places on their tongue, said co-inventor Dr. Boris Pasche at a...
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New treatment target for neuroendocrine prostate cancer discovered
by Roswell Park Comprehensive Cancer Center Mitochondria are dysfunctional in neuroendocrine prostate tumors. Credit: Oncogene (2024). DOI: 10.1038/s41388-024-03261-4 A team of researchers at Roswell Park Comprehensive Cancer Center, led by Dhyan Chandra, Ph.D., has discovered a new therapeutic target for neuroendocrine prostate cancer, a rare and hard-to-treat form of prostate cancer. Their findings, published in the journal Oncogene, suggest...
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Surprising discovery pinpoints when good cholesterol becomes harmful
by Houston Methodist HDL-free cholesterol (FC)spontaneously transfers to other phospholipid surfaces on a time scale of minutes. This schematic illustrates the consequences of FC transfer from FC-poor (Top) and FC-rich HDL (Bottom). The latter transfers more FC to than the former to other lipoproteins and the plasma membranes of cells, including macrophages. This difference may explain...
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CRISPR study silences gene mutations that drive aggressive cancers
by Peter MacCallum Cancer Centre Molecular principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adl0731 Peter Mac scientists have found a way to use the powerful gene editing tool CRISPR to silence cancer-causing gene mutations which, up to now, have remained off-limits to targeted drugs. ADVERTISING...
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How and why music can reduce distress in people with dementia: A blueprint for personalized music therapy
by Anglia Ruskin University Credit: Tima Miroshnichenko from Pexels A new study has demonstrated for the first time how and why music can reduce distress and agitation for people with advanced dementia. There are an estimated 1 million people living with dementia in the U.K., and more than half are diagnosed with advanced dementia, which can...
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Antibody leads to enhanced motor function in spinal cord injury patients: Clinical trial
by Kurt Bodenmüller, University of Zurich New nerve connections form. Credit: The Lancet Neurology (2024). DOI: 10.1016/S1474-4422(24)00447-2 Antibodies can improve the rehabilitation of people with acute spinal cord injury. Researchers at 13 clinics in Germany, Switzerland, the Czech Republic and Spain have investigated this with promising results. For the first time, it was possible to identify patient groups...