Abstract Objectives To evaluate the impact of total knee replacement on quality of life in people with knee osteoarthritis and to estimate associated differences in lifetime costs and quality adjusted life years (QALYs) according to use by level of symptoms. Design Marginal structural modeling and cost effectiveness analysis based on lifetime predictions for total knee...
Category: <span>Research Updates</span>
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Dragon blood may help wounds heal faster
A bacteria-fighting compound, based on a molecule from Komodo dragon blood, helped wounds heal faster in mice. In some myths, dragon’s blood is a toxic, vile substance. In others, it has magical properties, curing disease and making ordinary mortals invincible. When it comes to the blood of real-life Komodo dragons, both perspectives may contain a kernel...
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Ground-breaking app offering personalised rehabilitation programs for patients following stroke
Micrograph showing cortical pseudolaminar necrosis, a finding seen in strokes on medical imaging and at autopsy. H&E-LFB stain. Stroke is one of the world’s leading causes of disability so a first-of-its-kind app that supports clinicians to develop best practice rehabilitation strategies for patients with arm impairments following stroke is good news for millions of...
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Nanoparticle nasal spray may offer rapid and safe delivery of drugs to the brain
Traversing the blood-brain barrier is a challenge for drug developers. Now, after testing the method in locusts, a team of engineers shows how an aerosol nasal spray containing gold nanoparticles may offer a non-invasive and rapid way to deliver drugs to the brain. Researchers suggest that delivering drugs to the brain using nanoparticles in a...
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New approach makes cells resistant to HIV
Scientists at The Scripps Research Institute (TSRI) have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the virus. Their experiments under lab conditions show that these resistant cells can quickly replace diseased cells, potentially curing the disease in a person with HIV. “This protection would be long term,”...
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Potential new treatment to treat and stop progression of cystic fibrosis
Cystic fibrosis is a genetic disease that causes persistent lung infections and limits the ability to breathe over time. Researchers from the George Washington University (GW), the University of Perugia, and the University of Rome have discovered a potential new drug to treat and stop the progression of cystic fibrosis. Thymosin α1 (Tα1) is a...
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Stanford lab grows cornea cells for transplant
PALO ALTO — A Stanford research team has created a potentially powerful new way to fix damaged corneas — a major source of vision problems and blindness. Millions of new eye cells are being grown in a Palo Alto lab, enlisting one of medicine’s most important and promising new tools: refurbishing diseased and damaged tissue...
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Experimental drug turns ‘bad’ white fat into ‘good’ brown-like fat
Scientists say they know how white adipose cells — often called “bad fat” — can be converted into “good,” brown adipose in mice using little more than a synthetic stand-in for thyroid hormone. An experimental drug causes loss of weight and fat in mice, a new study has found. The study results will be presented...
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Tick tock, stay ahead of the aging clock
How does the epigenetic clock work? And is it possible to change the ticking rate? Ageing in humans (and animals) can be seen as either an inevitable process of wear and tear or as an inherent biological programme by which the lifespan of each species is more or less predetermined. Recent research has shown that...
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Retina cells could be integral to how our internal body clock works – and a cure for jet lag may be just around the corner
Cells in the eye are key to regulating humans’ circadian rhythm, according to a scientific study. Researchers at the University of Edinburgh found that a group of cells in the retina communicate directly with the region of the brain that deals with the body’s internal clock. All life forms respond to the daily light-dark changes...