The fight against cystic fibrosis (CF) has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones. IMAGE: GENE THERAPY TREATED AIRWAY STEM CELLS. The research published in the journal Stem Cell Research and Therapy applies cell transplantation therapy, normally used in bone marrow transplants to...
Category: <span>Research Updates</span>
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Researchers examining Parkinson’s resilience
Diseases have a spectrum of risk, even those partially embedded in genes such as Parkinson’s disease. C. elegans, seen here as hundreds living on a plate viewed through the lens of a microscope, share roughly half their genes with humans. Credit: the University of Alabama in Tuscaloosa Less than 10 percent of those with Parkinson’s...
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SSB1: Is there a way to delay the aging process, reverse DNA damage, and prevent cancer by restoring a natural protein in the body or turning it off?
To understand what therapeutics could benefit aging and DNA damage, we have to consider what molecules are involved. So, what do we know about this process? There are a number of factors that are involved in the aging process. Many things such as diet, lifestyle, medication, genetics, diseases, amongst countless others, are involved. However, in...
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The 3 Best Peptide and Stem Cell Combinations with Great Therapeutic Potential
Current medical therapies fail to restore tissue damage due to degenerative conditions, normal aging processes, ischemia and traumatic injuries. Tissue regeneration and organ engineering have shown promise as novel treatment strategies for patients requiring tissue or whole organ replacement. Modern approaches to regenerative tissue therapies typically revolve around the use of stem cells.[i] The development of pluripotent...
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Mitochondrial Peptides: Their Effect on Aging
Published 07/25/18 Mitochondria have long been recognized as the metabolic powerhouse in the body, and their functionality is critical to a number of processes. Interestingly, in recent years their role in signaling is being consistently appreciated. Thus, identifying reading frames that encode peptides has been a crucial component of research. One peptide that has been a huge...
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New stem cell model can be used to test treatments for a rare nervous system disorder
A City of Hope researcher has developed a stem cell model to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). An Alexander disease patient’s stem cell-derived astrocytes (green) inhibits the growth of precursor cells that become myelin...
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New anti-cancer drugs put cancers to sleep—permanently
In a world first, Melbourne scientists have discovered a new type of anti-cancer drug that can put cancer cells into a permanent sleep, without the harmful side-effects caused by conventional cancer therapies. Killer T cells surround a cancer cell. Credit: NIH Published today in the journal Nature, the research reveals the first class of anti-cancer drugs that work by putting...
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Cancer cells are weaker when made more acidic
Cancer cells function less well and are less able to multiply when their internal environment is made more acidic. Making cancer cells more acidic could quell their ability to multiply. This was the conclusion that researchers in the United States and Spain came to after they used a computer model to study the conditions that affect metabolic...
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Newly characterized molecule offers possibilities for novel Alzheimer’s treatments
Alzheimer’s disease is an increasingly prevalent, neurodegenerative condition that erodes memory and other cognitive functions. Treatments for this complex disease have been elusive, although researchers have previously uncovered its main biological features: amyloid-beta plaques and tau tangles. PET scan of a human brain with Alzheimer’s disease. Credit: public domain A study by researchers from Brigham and Women’s Hospital (BWH),...
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Metabolomics applications for precision nutrition, formula, and Neurodegenerative disorders
Metabolomics is the latest omics systems science technology with emerging applications towards psychiatry, personalized medicine, and most recently, precision nutrition research. Infant formula, for example, is manufactured to match the molecular composition of human milk. A new study reporting on the comparative lipid profiles of infant formulas and human milk using metabolomics is published in OMICS: A...