Peer-Reviewed Publication InSilico Medicine image: The study, published in Nature Biotechnology, highlights the role of Chemistry42 and its submodules in supporting drug candidate design and optimization. The research underscores the potential of advanced AI technologies to accelerate the fulfillment of urgent clinical needs.view more Credit: Insilico Medicine Inflammatory bowel disease (IBD), consisting primarily of ulcerative colitis and...
Category: <span>Research Updates</span>
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New treatment may delay cancer in high-risk myeloma
by Kelley Luckstein, Mayo Clinic Credit: Mayo Clinic A new treatment is showing promise for people with high-risk smoldering multiple myeloma (SMM). This precancerous condition can progress to active multiple myeloma, a type of blood cancer. High-risk SMM carries a higher likelihood of progression. Results from a phase 3 clinical trial, published in the New England Journal of Medicine and...
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Cardiorespiratory fitness linked to preservation of cognitive abilities in older age
by British Medical Journal Credit: Pixabay/CC0 Public Domain Higher cardiorespiratory fitness in older age is linked to the preservation of several core aspects of cognitive ability that are vulnerable to age-related decline, finds research published online in the British Journal of Sports Medicine. And this association holds true irrespective of key risk factors for cognitive decline: age and...
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First vaccine against blood-stage malaria is well-tolerated and offers effective protection in clinical trial
by University of Oxford Credit: CDC The results of a clinical trial into a new malaria vaccine candidate (RH5.1/Matrix-MTM) show it is well-tolerated and offers effective protection against the blood-stage of the disease—the first inoculation to do so. Malaria, caused by Plasmodium falciparum parasites, is a leading cause of death in children under five in many parts of...
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Research shows fasting, bandage combo restores bone healing in mice
by eLife Credit: eLife (2024). DOI: 10.7554/eLife.104068.1 A combination of intermittent fasting and a specialized biomedical bandage can restore bone healing in aged mice to levels seen in young animals, according to new research. The scientists say rigorous analysis provides compelling evidence for the potential new therapeutic approach, with the promise for also rejuvenating repair across other tissues....
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X-chromosome study reveals hidden genetic links to Alzheimer’s disease
By Hugo Francisco de SouzaReviewed by Susha Cheriyedath, M.Sc.Dec 9 2024 Despite decades of research, the X-chromosome’s impact on Alzheimer’s was largely ignored until now. Explore how seven newly discovered genetic loci could revolutionize our understanding of the disease. Study: X‐chromosome-wide association study for Alzheimer’s disease. Image Credit: nobeastsofierce / Shutterstock Conventional investigations of the genetic contributors to Alzheimer’s disease...
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1 GENE MAY PUT YOU AT HIGHER RISK OF BREAST CANCER’S SPREAD
DECEMBER 10TH, 2024POSTED BY KATHERINE FENZ-ROCKEFELLER (Credit: Getty Images) SHARE THIS ARTICLE You are free to share this article under the Attribution 4.0 International license. TAGS UNIVERSITY ROCKEFELLER UNIVERSITY Researchers have discovered a genetic predisposition that increases the risk of breast cancer metastasis. Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original...
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Identifying a proliferating repairman for tissue in damaged lungs
Penn Vet and Penn Medicine researchers found that endothelial cells lining the veins in lungs contribute to repair of blood vessels after lung injuryPeer-Reviewed Publication University of Pennsylvania Veins in the lungs, or pulmonary veins, play a critical role not only in lung functioning but also in maintaining sufficient oxygen in tissue throughout the body....
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Brain volume changes seen in opioid users
Peer-Reviewed Publication Radiological Society of North America image: Tensor-based morphometry (TBM) analysis of T1-weighted MRI scans shows a comparison of brain volumes in participants with opioid use disorder (OUD) and healthy control participants. Widespread volume differences are observed between participants with OUD and healthy controls when accounting for total brain volume. Specifically, the bilateral thalamus,...
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Portable MRI shows promise for expanding brain imaging for Alzheimer’s disease
By leveraging machine learning tools, Mass General Brigham researchers measured markers of Alzheimer’s disease on portable MRI with accuracy matching that of standard MRIPeer-Reviewed Publication Massachusetts General Hospital Globally, approximately 139 million people are expected to have Alzheimer’s disease (AD) by 2050. Magnetic resonance imaging (MRI) is an important tool for identifying changes in brain...