Penn Vet and Penn Medicine researchers found that endothelial cells lining the veins in lungs contribute to repair of blood vessels after lung injuryPeer-Reviewed Publication University of Pennsylvania Veins in the lungs, or pulmonary veins, play a critical role not only in lung functioning but also in maintaining sufficient oxygen in tissue throughout the body....
Category: <span>Research Updates</span>
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Brain volume changes seen in opioid users
Peer-Reviewed Publication Radiological Society of North America image: Tensor-based morphometry (TBM) analysis of T1-weighted MRI scans shows a comparison of brain volumes in participants with opioid use disorder (OUD) and healthy control participants. Widespread volume differences are observed between participants with OUD and healthy controls when accounting for total brain volume. Specifically, the bilateral thalamus,...
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Portable MRI shows promise for expanding brain imaging for Alzheimer’s disease
By leveraging machine learning tools, Mass General Brigham researchers measured markers of Alzheimer’s disease on portable MRI with accuracy matching that of standard MRIPeer-Reviewed Publication Massachusetts General Hospital Globally, approximately 139 million people are expected to have Alzheimer’s disease (AD) by 2050. Magnetic resonance imaging (MRI) is an important tool for identifying changes in brain...
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New gene therapy reverses heart failure in large animal model
by University of Utah Health Sciences Fluorescent microscope image of previously failing heart cells that have received cBIN1 gene therapy. Green is a label that indicates the location of cell membranes. The green stripes indicate that the microscopic architecture of heart cells is closer to normal. Credit: Hong lab A new gene therapy can reverse the...
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Cortisol spikes cause debilitating bone growth in spinal injury patients
by University of Queensland Credit: Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101849 Queensland researchers have solved the century-old mystery of why patients who suffer severe spinal cord and brain injuries develop debilitating bone growths around joints such as hips and shoulders. Neurogenic heterotopic ossification (NHO) affects about 20% of patients who suffer spinal cord injuries and can lead to a complete loss of...
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Empagliflozin linked to reduced progression of diabetic retinopathy
by Justin Jackson , Medical Xpress Credit: Mikhail Nilov from Pexels An investigation led by Brigham and Women’s Hospital finds empagliflozin (sold as Jardiance) may reduce the risk of diabetic retinopathy (DR) progression in patients with a history of nonproliferative diabetic retinopathy (NPDR) but showed no association with preventing new NPDR onset. DR is one...
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GLP-1 meds may lower clot risk in people with diabetes
by Ernie Mundell People with diabetes who are taking GLP-1 meds such as Ozempic or Mounjaro may be getting an added bonus: Reductions in their odds for a dangerous blood clot, new research finds. The study found that folks with diabetes who were using the drugs lowered their odds for a form of clot called venous thromboembolism (VTE) by 20%, compared...
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Itacitinib helps prevent graft versus host disease in stem cell transplant recipients
by Elana Gotkine Credit: CC0 Public Domain For patients with haploidentical hematopoietic cell transplantation (haplo-HCT), the addition of itacitinib to standard graft versus host disease (GvHD) prophylaxis is well tolerated and results in low rates of cytokine release syndrome (CRS), according to a study published online Nov. 2 in Blood. Noting that posttransplant cyclophosphamide (PtCy) has improved GvHD prophylaxis in...
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Estrous rhythm found crucial for optimizing breast cancer therapy
by Justin Jackson, Medical Xpress Oestrous cycle-dependent proliferation of tumor cells during oestrus stage in MMTV-PyMT tumors. Credit: Nature (2024). DOI: 10.1038/s41586-024-08276-1 The Netherlands Cancer Institute has found that the estrous cycle stage significantly influences mammary tumors’ sensitivity to chemotherapy. In mouse models of breast cancer, treatment initiated during the diestrus stage resulted in reduced responses to...
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Analysis offers new explanation for dangerous atherosclerotic plaques in type 2 diabetes
by Lund University Less collagen and vascular smooth muscle cells are associated with future cardiovascular events in type 2 diabetes. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50753-8 People with type 2 diabetes have a higher risk of suffering a stroke, a heart attack and premature death due to atherosclerosis, but it has been unclear what the underlying mechanisms are....