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Novel mechanism in brain blood flow regulation offers insights into treating stroke and dementia

by University of Vermont Credit: Pixabay/CC0 Public Domain A team of UVM scientists led by Mark Nelson, Ph.D., from the Larner College of Medicine at the University of Vermont, has uncovered a novel mechanism that reshapes our understanding of how blood flow is regulated in the brain. The study, published in The Proceedings of the National Academy...

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Genetic code discovery could redefine understanding of cancer origins

by Virginia Commonwealth University Tumor cells synthesize and export Tu-Stroma to stromal cells via DDX3X-assisted exosomal packaging. Credit: Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02453-3 A group of scientists at VCU Massey Comprehensive Cancer Center has revealed a new genetic code that acts like a cancer ringleader, recruiting and deploying a gang of tumor cells to incite a biological turf...

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Researchers discover a way to make fat cells skinny

Posted Yesterday Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered a key biological reason why obesity increases the risk of Type 2 diabetes, and it boils down to size — specifically the size of fat cells. Fat – illustrative photo. Image credit: Pixabay (Free Pixabay license) The study, published in...

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African men most at risk of prostate cancer—new study flags genetic causes

by Wenlong Carl Chen, The Conversation Credit: Unsplash/CC0 Public Domain A breakthrough study has identified the genetic risk factors that contribute to increased prostate cancer in African men. The study, the largest of its kind, recruited 7,500 men from eastern, southern and west Africa. The study is especially important because African men have a high risk...

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New research reveals two types of fatty liver disease

by Karolinska Institutet Putative model of the two different types of MASLD. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03284-0 Researchers at Karolinska Institutet and the University of Gothenburg have identified two types of metabolic-associated fatty liver disease—a liver-specific type and a systemic type that affects other organs and tissues. The discovery could lead to improved diagnosis and treatment of...

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Stomach cancer can be caused by a bacterium carried by half the people on Earth, but screening for it isn’t easy

by Delthia Ricks , Medical Xpress Credit: Pixabay/CC0 Public Domain In 1982, two Australian physician–scientists discovered a spiral-shaped bacterium whose form not only dictated its function, but its capacity to dwell in the human body’s harshest chemical environment would help identify it as the cause of serious afflictions of the stomach, including cancer. Drs. Barry...

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Neuron-based research model helps decode rare neurological disease

by Tel-Aviv University Differential effects of TIMM50 mutation on the expression of TIM23, PAM and TOM subunits and matrix-destined proteins. Credit: eLife (2024). DOI: 10.7554/eLife.99914.2 Researchers at Tel Aviv University have developed an innovative research model that allowed them to decode the mechanism underlying a severe and rare neurological disease. The disease is characterized by symptoms such as...

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MASH discovery redefines subtypes with distinct risks: shaping the future of fatty liver disease treatment

Peer-Reviewed Publication INSERM (Institut national de la santé et de la recherche médicale) Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population. The disease spans from benign fat accumulation in the liver (steatosis) to its more severe form, metabolic dysfunction-associated steatohepatitis...

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Study links high-fiber diet to delayed progression of blood cancer

by Memorial Sloan Kettering Cancer Center Credit: Unsplash/CC0 Public Domain Researchers at Memorial Sloan Kettering Cancer Center (MSK) have reported results from the first-ever clinical trial demonstrating that a high-fiber, plant-based dietary intervention may delay progression to multiple myeloma, a rare and incurable blood cancer affecting the bone marrow. The study enrolled 20 participants with a precancerous blood...