by Ernie Mundell People with diabetes who are taking GLP-1 meds such as Ozempic or Mounjaro may be getting an added bonus: Reductions in their odds for a dangerous blood clot, new research finds. The study found that folks with diabetes who were using the drugs lowered their odds for a form of clot called venous thromboembolism (VTE) by 20%, compared...
Category: <span>Research Updates</span>
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Itacitinib helps prevent graft versus host disease in stem cell transplant recipients
by Elana Gotkine Credit: CC0 Public Domain For patients with haploidentical hematopoietic cell transplantation (haplo-HCT), the addition of itacitinib to standard graft versus host disease (GvHD) prophylaxis is well tolerated and results in low rates of cytokine release syndrome (CRS), according to a study published online Nov. 2 in Blood. Noting that posttransplant cyclophosphamide (PtCy) has improved GvHD prophylaxis in...
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Estrous rhythm found crucial for optimizing breast cancer therapy
by Justin Jackson, Medical Xpress Oestrous cycle-dependent proliferation of tumor cells during oestrus stage in MMTV-PyMT tumors. Credit: Nature (2024). DOI: 10.1038/s41586-024-08276-1 The Netherlands Cancer Institute has found that the estrous cycle stage significantly influences mammary tumors’ sensitivity to chemotherapy. In mouse models of breast cancer, treatment initiated during the diestrus stage resulted in reduced responses to...
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Analysis offers new explanation for dangerous atherosclerotic plaques in type 2 diabetes
by Lund University Less collagen and vascular smooth muscle cells are associated with future cardiovascular events in type 2 diabetes. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50753-8 People with type 2 diabetes have a higher risk of suffering a stroke, a heart attack and premature death due to atherosclerosis, but it has been unclear what the underlying mechanisms are....
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Novel mechanism in brain blood flow regulation offers insights into treating stroke and dementia
by University of Vermont Credit: Pixabay/CC0 Public Domain A team of UVM scientists led by Mark Nelson, Ph.D., from the Larner College of Medicine at the University of Vermont, has uncovered a novel mechanism that reshapes our understanding of how blood flow is regulated in the brain. The study, published in The Proceedings of the National Academy...
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Genetic code discovery could redefine understanding of cancer origins
by Virginia Commonwealth University Tumor cells synthesize and export Tu-Stroma to stromal cells via DDX3X-assisted exosomal packaging. Credit: Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02453-3 A group of scientists at VCU Massey Comprehensive Cancer Center has revealed a new genetic code that acts like a cancer ringleader, recruiting and deploying a gang of tumor cells to incite a biological turf...
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Researchers discover a way to make fat cells skinny
Posted Yesterday Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered a key biological reason why obesity increases the risk of Type 2 diabetes, and it boils down to size — specifically the size of fat cells. Fat – illustrative photo. Image credit: Pixabay (Free Pixabay license) The study, published in...
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African men most at risk of prostate cancer—new study flags genetic causes
by Wenlong Carl Chen, The Conversation Credit: Unsplash/CC0 Public Domain A breakthrough study has identified the genetic risk factors that contribute to increased prostate cancer in African men. The study, the largest of its kind, recruited 7,500 men from eastern, southern and west Africa. The study is especially important because African men have a high risk...
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New research reveals two types of fatty liver disease
by Karolinska Institutet Putative model of the two different types of MASLD. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03284-0 Researchers at Karolinska Institutet and the University of Gothenburg have identified two types of metabolic-associated fatty liver disease—a liver-specific type and a systemic type that affects other organs and tissues. The discovery could lead to improved diagnosis and treatment of...
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Stomach cancer can be caused by a bacterium carried by half the people on Earth, but screening for it isn’t easy
by Delthia Ricks , Medical Xpress Credit: Pixabay/CC0 Public Domain In 1982, two Australian physician–scientists discovered a spiral-shaped bacterium whose form not only dictated its function, but its capacity to dwell in the human body’s harshest chemical environment would help identify it as the cause of serious afflictions of the stomach, including cancer. Drs. Barry...