Peer-Reviewed Publication Compuscript Ltd FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Characteristics of ferroptosis. (A) Morphological and biochemical characteristics of ferroptosis. (B) Core regulatory proteins of ferroptosis. Image link: https://ars.els-cdn.com/content/image/1-s2.0-S2352304224002484-gr1_lrg.jpg view more Credit: Genes & Diseases Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional Chinese Medicine (TCM) can effectively modulate ferroptosis,...
Category: <span>Research Updates</span>
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A more affordable, lower-risk polio vaccine may be on the horizon
by University of Leeds Microscopic image of poliovirus. Credit University of Leeds. Credit: University of Leeds University of Leeds researchers have taken a major step towards producing a more affordable and lower-risk polio vaccine using virus-like particles (VLPs). These particles mimic the outer protein shell of poliovirus, but are empty inside. This means there is no...
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AI Tool Diagnoses Multiple Diseases From One Blood Sample
Lucy Hicks March 07, 2025 2180 Added to Email Alert A new artificial intelligence (AI) tool can simultaneously assess blood samples for infections, autoimmune diseases, and vaccine responses, according to a new study. The algorithm analyzed genes encoding immune cell receptors to identify patients with COVID-19, HIV, type 1 diabetes, lupus, those who recently received...
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Genes combined with immune response to Epstein-Barr virus increase MS risk, study finds
by Karolinska Institutet Credit: Unsplash/CC0 Public Domain In multiple sclerosis (MS), antibodies to the common Epstein-Barr virus can accidentally attack a protein in the brain and spinal cord. New research shows that the combination of certain viral antibodies and genetic risk factors can be linked to a greatly increased risk of MS. The study, led by...
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Intranasal herpes infection may produce neurobehavioral symptoms
by University of Illinois at Chicago Overall schematic of HPSE-mediated neuroinflammation. After HSV-1 infection, HPSE was involved in cascade of events leading to inflammasome formation and caspase activation along with proinflammatory cytokine upregulation and gasdermin-mediated cell death. The above series of events leads to neuroinflammation and cell death. Credit: mBio (2025). DOI: 10.1128/mbio.03765-24 Herpes simplex virus-1 (HSV-1) is...
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Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer’s disease
by The Scripps Research Institute Microscopy images show fluorescently stained mouse brains expressing genes that cause Alzheimer’s disease. Compared with an Alzheimer’s-like brain (left), the more intense green color (right) indicates more neuronal synapses—connections between nerve cells that underlie learning and memory—upon treatment with the drug diAcCA. Credit: Scripps Research The herb rosemary has long been...
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FLIpping the switch: DNA regulator activates blood stem cells for improved transplantation success
by Weill Cornell Medical College Adult mobilized hematopoietic stem/progenitor cells (HSPCs) into which Fli-1 modified mRNA has been introduced are shown expanding on top of engineered vascular endothelial cells (ECs). The greyscale image has been colorized with ECs (large, spread, and spindle shaped) and HSPCs colored blue (small and roundish) and the boundaries for HSPCs emphasized...
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In quest to construct a better flu shot, scientists zero in on tiny flu protein shaped like a mushroom
by Delthia Ricks , Medical Xpress Cryo-EM Details of c115.131 and c968.180 Fab with H10 HA trimer. Credit: Science Translational Medicine (2025). DOI: 10.1126/scitranslmed.adr8373 Not long after the first flu shot was introduced in 1945 by University of Michigan virologist Thomas Francis and his co-researcher, Jonas Salk (who would later garner worldwide fame as developer of the...
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Risk for specific hematologic cancers down with GLP-1 receptor agonist use in type 2 diabetes
by Elana Gotkine For patients with type 2 diabetes (T2D), glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with a reduced risk for developing hematologic cancers compared with insulin and metformin use, according to a research letter published online March 6 in JAMA Network Open. Omer S. Ashruf, from Northeast Ohio Medical University in Rootstown, and colleagues...
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In the body, psilocybin becomes psilocin, which can increase nerve cell communication even in a single dose
by Torsten Lauer, Zentralinstitut für Seelische Gesundheit Validation of mature cortical neuron properties and effect of psilocin on cell surface-located 5-HT2A receptor presentation. Credit: eLife (2025). DOI: 10.7554/eLife.104006.1 A recent study by the Hector Institute for Translational Brain Research (HITBR) at the Central Institute of Mental Health (CIMH) in Mannheim provides the first detailed cellular insights into...