by University College London Credit: Karolina Grabowska from Pexels Our organs age at different rates, and a blood test determining how much they’ve each aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study led by University College London (UCL) researchers. The findings, published in The Lancet Digital Health, show...
Category: <span>Research Updates</span>
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Childhood long COVID might be caused by lower blood flow in lungs, scans suggest
by Dennis Thompson Children and teens with long COVID appear to have significantly reduced blood flow through their lungs, researchers reported in the journal Radiology. This could cause fatigue—one of the more common symptoms of long COVID in children—due to lower levels of oxygen distributed throughout the body via the bloodstream, researchers said. The study’s results...
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Longer vs Shorter Antibiotic Duration Shows Similar Outcomes in Older Adults
Edited by Archita Rai February 05, 2025 056 TOPLINE: Longer (8-14 days) antibiotic courses were not associated with increased antibiotic-associated adverse effects or benefits than shorter (3-7 days) antibiotic courses in community-dwelling older adults. METHODOLOGY: TAKEAWAY: IN PRACTICE: “[The study] findings may suggest that in community-dwelling patients who are at lower risk of harms and...
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RORγt⁺ dendritic cells play both offense and defense: Versatile immune cell offers new therapeutic approaches
by Ludwig Maximilian University of Munich Single-cell multiomic profiling reveals the unique identity of RORγt+ DCs. Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2417308122 LMU researchers have shown that a particular type of immune cell acts more flexibly than previously thought—with the potential for new therapeutic approaches. As part of the innate immune system, dendritic...
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Potbelly may be a sign of brain aging
Peer-Reviewed Publication Toho University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: This figure illustrates a putative relationship between adipose CX3CL1 and brain BDNF, and its age-related changes. In young mice, steroid hormones contribute to maintaining brain BDNF levels via adipose CX3CL1. However, in aged mice, a deficiency of adipose 11β-HSD1 leads to insensitivity to steroid hormones, which in turn decreases...
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Novel therapy being tested for treating rheumatic fever
by Griffith University LD-IL-2 therapy induces functional improvement of the heart and reduces carditis. Credit: mBio (2025). DOI: 10.1128/mbio.03823-24 Painful monthly penicillin injections could be a thing of the past as Griffith University researchers, in collaboration with researchers at the University of New England, are investigating the benefits of an alternative therapy for children diagnosed with rheumatic fever....
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AI model can read ECGs to identify female patients at higher risk of heart disease
by Imperial College London Credit: CC0 Public Domain A new AI model can flag female patients who are at higher risk of heart disease based on an electrocardiogram (ECG). The researchers say the algorithm, designed specifically for female patients, could enable doctors to identify high-risk women earlier, enabling better treatment and care. Details are published in The Lancet Digital...
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Novel Triple Combination Therapy May Transform Cystic Fibrosis Care in Children
Edited by Shreyasi Asthana February 18, 2025 13 TOPLINE: A 24-week phase 3 trial has found that once-daily vanzacaftor-tezacaftor-deutivacaftor is generally safe and well tolerated in children with cystic fibrosis aged 6-11 years. The treatment maintains normal baseline lung function while improving cystic fibrosis transmembrane conductance regulator (CFTR) function. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Once-daily treatment...
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DNA methylation as a biomarker for early diagnosis of lung cancer
Methylation profiles of cancer-related CpG sites in tissue and plasma serve as biomarker for early diagnosis of non-small cell lung cancer.Peer-Reviewed Publication Compuscript Ltd FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: A) Unsupervised hierarchical clustering of 276 differential methylation sites selected in the tissue samples. (B) The methylation levels of 6 differential methylation sites selected for the diagnostic prediction model. (C, D) Receiver operator characteristic...
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Novel bone marrow transplant can cure sickle cell disease
Peer-Reviewed Publication Johns Hopkins Medicine FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail A bone marrow transplant process co-developed by investigators at the Johns Hopkins Kimmel Cancer Center is safe and curative for adults with sickle cell disease, according to results of a trial completed at Johns Hopkins and about 20 additional cancer centers nationwide and in London. The treatment, available at multiple U.S....