A University of Michigan-led study is shedding new light on the way pancreatic cancer cells turn nearby connective tissue cells into co-conspirators in their deadly growth. The findings, which appear in Nature Metabolism, also suggest a new potential strategy against pancreatic cancer by identifying critical components of metabolic cross-talk between cells that might be attacked...
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Fast-spreading mutation helps common flu subtype escape immune response
by Johns Hopkins University Bloomberg School of Public Health Strains of a common subtype of influenza virus, H3N2, have almost universally acquired a mutation that effectively blocks antibodies from binding to a key viral protein, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health. The results have implications for flu...
How cells’ ‘lava lamp’ effect could make cancer drugs more powerful
Discovery that synthetic compounds form concentrated droplets inside cells could shake up drug development — including the hunt for coronavirus treatments. Fluorescently tagged molecules of the cancer drug cisplatin clump up inside droplets in cells.Credit: Isaac Klein/Whitehead Institute There’s a long-standing assumption in the pharmaceutical industry that when drug molecules enter a cell, they spread...
Little-studied immune cell may be key to activating energy-burning ‘beige fat’
by University of New South Wales Immune cells called eosinophils could be an essential part of the process that activates “beige fat,” a study in mice published this week in Nature Communications shows. If future research confirms this hypothesis, these cells may be a target for anti-obesity therapies down the track. There are three types...
What the phase 1 trials of the first COVID-19 vaccine really mean
by Sanjay Mishra, The Conversation Rather than provide a vaccine made from viral proteins, Moderna’s COVID-19 vaccine is composed of synthetic viral mRNA. These molecules are injected into people and cellular protein-making machines, called ribosomes, read and translate the mRNA. It’s these proteins that then trigger an immune response. Credit: The Conversation, CC BY-SA Early morning on...
How do you stay safe now that states are reopening? An expert explains how to assess risk when reconnecting with friends and family
How do you stay safe now that states are reopening? An expert explains how to assess risk when reconnecting with friends and family May 18, 2020 8.20am EDT Author Ryan Malosh Assistant Research Scientist, University of Michigan Disclosure statement Ryan Malosh receives salary support from the Centers for Disease Control and Prevention (CDC) and the...
Reducing early brain inflammation could slow Alzheimer’s progression
CREDIT: GIORGIA MENEGONI, SAPIENZA, UNIVERSITY OF ROME Bethesda, MD – In a new animal study examining Alzheimer’s disease, researchers found that disease progression could be slowed by decreasing neuroinflammation in the brain before memory problems and cognitive impairment were apparent. The new findings point to the importance of developing therapies that target very early stages...
Expert reveals why you’re feeling so tired during lockdown – and the simple four-step routine to fix it
Sleep expert Olivia Arezzolo said you feel more tired than ever for a reason Your body has been trying to deal with the ongoing stress of COVID-19 Many of us are in the ‘exhaustion phase’ right now with high cortisol levels Olivia’s four-step routine includes taking magnesium and having a bed routine While you may...
U.S. pharmacists can now test for coronavirus. They could do more if government allowed it
by Steven W. Chen, The Conversation As Italy’s death toll from the novel coronavirus climbed to one of the highest in the world, its doctors made a plea to other countries: Manage the pandemic in the community, not in hospitals and emergency rooms. When people with COVID-19 show up at hospitals, they can spread the...
New rapid diagnostic test for peritonitis used for first time in patients
by Cardiff University A new diagnostic test for peritonitis underpinned by Cardiff University-led research has been used for the time in patients. The Periplex test was trialled in more than 100 patients at the Royal Free Hospital in London in an independent study led by Dr. Cate Goodlad, with “promising” results that suggest it could...