By Maya Goldman |
![]() ![]() from 1440 Daily Digest:Degenerated Muscles RestoredA trio of patients suffering from spinal muscular atrophy saw significant improvements in their muscle function while receiving electrical stimulation in their lower spines, according to research released yesterday. The process is the first neurotechnology to reverse the decay of nerve circuitry and revive cell function in patients with a neurodegenerative disease. Spinal muscular atrophy is a rare, inherited disease that gradually kills off spinal nerve cells responsible for muscle movement (how it works). As the so-called motor neurons die, the muscles they control wither, causing significant mobility issues. There is currently no cure, though treatments exist to slow the disease’s progression. In the trial, two spinal cord stimulation electrodes implanted in three individuals with the disease’s milder form (Types 3 or 4) were stimulated for four hours at a time over 29 days. During the test period, each patient saw gains in leg strength, walking distance, and more, though upon removal, the implant’s benefits faded. Larger clinical trials are expected, as well as applications to other neurodegenerative diseases. from STAT: biotechThe CRISPR companies are not OKPhoto illustration: Christine Kao/STAT; Photos: AdobeThe gene editing tool CRIPSR was supposed to change medicine — just five years ago, a Nobel Prize committee announced that it “may make the dream of curing inherited diseases come true.” Billions of dollars were spent chasing that dream, but key scientific hurdles remained unsolved. Now, even when companies achieve encouraging results, that can’t seem to stop their stocks from tanking. Put simply, STAT’s Jason Mast writes, “there are surprisingly few places today where you can both cure a disease with gene editing and make money.” For his latest story, Jason interviewed more than 75 investors, academics, executives, analysts, and employees to figure out where, exactly, the vision went off course. Read more. (Come for the analysis and stay for the similes. In one section about the hype around CRISPR, Jason describes it “like dropping a 3D printer into a medieval workshop.” Later, he says the tool has become “as indispensable to lab scientists as whisks are to pastry chefs.”)TelehealthAmazon Pharmacy study touts refill rate ![]() DealsNew Teladoc, same acquisition strategyOn Wednesday I reported that virtual care giant Teladoc Health plans to buy Catapult Health for $65 million. Catapult makes a kit that allows people to take their blood pressure and a blood sample for lab testing at home. After mailing in their sample, people meet with a nurse practitioner to discuss the results. The purchase is aimed at growing Teladoc’s chronic disease business and is very much in line with Teladoc strategies going back years.First of all, Teladoc has always been a rollup. Before the pandemic helped Teladoc Health grow from earning $500 million a year to $2.6 billion a year, the company steadily built the foundation for this growth by strategically acquiring companies here and there. These days, people like me are constantly reminding you about the company’s record-breaking $18.5 billion deal to buy digital diabetes management company Livongo, which ultimately led to Teladoc writing off billions in losses. But it’s been a mostly good strategy: The company bought BetterHelp in 2015 for a song and has since grown it to a $1 billion business on its own. (BetterHelp is having some issues these days, but we’ll set that aside for now.)Amid growth that has slowed to a crawl, Teladoc last year replaced its CEO. New leader Chuck Divita has made some internal changes and pushed new priorities, like international expansion, but the new purchase shows how much of Teladoc’s strategy is more of the same. With 93 million people eligible for Teladoc services, the company’s main lever for growth in the United States, its biggest market, remains getting eligible people to use its more services. The hope, dating back to the Livongo purchase, is that more people using Teladoc for virtual urgent care would eventually use its chronic disease offerings. Now it’s got a home testing company to support that goal.Read more about the deal here. |
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