by Elana Gotkine For adults with severe alopecia areata (AA), ivarmacitinib, a selective Janus kinase 1 (JAK1) inhibitor, at doses of 4 and 8 mg is efficacious and tolerable, according to a study presented at the annual meeting of the American Academy of Dermatology, held from March 7 to 11 in Orlando, Florida. Jianzhong Zhang, M.D.,...
Tag: <span>Alopecia</span>
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Ritlecitinib Shows Long-Term Benefits in Alopecia Areata
Edited by Gargi Mukherjee February 06, 2025 1116 Add to Email Alerts TOPLINE: Ritlecitinib demonstrates long-term improvements in regrowth of scalp hair, eyebrows, and eyelashes at 24 months in adults and adolescents with alopecia areata (AA) and ≥ 25% scalp hair loss. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Long-term treatment with ritlecitinib 50 mg QD (with a...
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Scientists discover new gene-to-gene interaction increasing risk of alopecia
Peer-Reviewed Publication King’s College London FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Scientists have discovered an interaction between genes that increases the risk of developing a type of alopecia. In a new JAMA Dermatology study, scientists at King’s College London found that changes in two parts of the genome work together to influence alopecia risk. Frontal fibrosing alopecia (FFA) is a highly distressing...
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Researchers identify risk factors for poor prognosis in alopecia areata
by Inka Väth, University Hospital of Bonn Credit: Pixabay/CC0 Public Domain Alopecia areata (AA) is a common autoimmune disease that leads to sudden circular hair loss. The clinical course of AA is unpredictable and varies greatly from individual to individual. Numerous studies have shown that AA is often associated with comorbid, i.e. co-existing, chronic inflammatory diseases,...
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Topical JAK Inhibitor Shows Promise for Frontal Fibrosing Alopecia
AMSTERDAM — For frontal fibrosing alopecia (FFA), a disease with no approved therapies, topical delgocitinib attenuated inflammation and generated hair regrowth in women in a controlled phase 2a trial. “This is an exciting avenue for FFA if the data are recapitulated in a larger population. It could be an important new treatment option,” said Maryanne Senna, MD,...
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Alopecia Areata: What Happens When Baricitinib Responders Stop Treatment?
Medscape Medical News > MedBrief Deepa Varma August 14, 2024 TOPLINE:Among patients with severe alopecia areata (AA) who have significant hair growth with baricitinib, continuing treatment is needed to maintain hair regrowth, according to the results of a randomized study. METHODOLOGY:Researchers conducted a treatment withdrawal substudy of a randomized, placebo-controlled, phase 3 clinical trial, BRAVE-AA1,...
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Study Estimates Post-COVID Risk for Alopecia Areata
Infection with COVID-19 conferred a nearly twofold risk of developing alopecia areata (AA), results from a large analysis of Korean patients demonstrated. “There is a growing number of reports on new onset, exacerbation, and recurrence of AA after COVID-19,” corresponding author Jin Park, MD, PhD, of the Department of dermatology at Jeonbuk National University Medical...
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People with alopecia found to have higher risk for inflammatory arthritis
by Lori Solomon Alopecia areata (AA) is associated with a higher risk for inflammatory arthritis, according to a study published online April 28 in the Journal of the American Academy of Dermatology. Colin M. Kincaid, from University of California at Irvine, and colleagues used medical records from 75 health care organizations (TriNetx) to determine if an association exists between...
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Stem cell topical solution for baldness offers positive trial results
By Rich Haridy May 18, 2020 South Korean researchers have shown a stem-cell-based topical solution can regrow hair in both male and female subjects with common pattern baldness. The small, randomized, placebo-controlled trial found the treatment both safe and effective, with larger trials hoped to validate the results in more diverse populations. The most common...
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Mice with patchy coats lay bare how stem cells endure
Whether we like it or not, our hair continually grows. Its regenerative powers reside deep inside each hair follicle, in a cluster of dividing stem cells—some of which will specialize and eventually give rise to new hair while others will produce new stem cells. Scientists have delineated numerous mechanisms that guide stem cells toward particular...
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