Mutations in plasma cells play a key role in light chain amyloidosis TECHNICAL UNIVERSITY OF MUNICH (TUM) Bone marrow plasma cells produce antibodies. These comprise two long and two short protein chains. The pathological proliferation of plasma cells can lead to an overproduction of the short chains. These associate to fibrils and deposit in organs....
by Max Planck Society If the immune system attacks its own body, it can often have devastating consequences: autoantibodies bind to the body’s structures, triggering functional disorders. The receptors for glutamate, a neurotransmitter, can also become the target of autoantibodies. Researchers at the Max Planck Institute of Experimental Medicine in Göttingen have been investigating the...
Sponsored Content by St John’s Laboratory Enzyme Linked Immunosorbent Assay (ELISA) is a basic, sensitive, reliable, and efficient analytical method employed for the quantification and detection of protein biomarkers in immunoassays.1 How Does an ELISA Work? The ELISA method is established on the strength of the interaction between an antigen and an antibody, frequently called the binding specificity and...
BOSTON MEDICAL CENTER BOSTON – Current HIV-1 therapies have been proven to be highly effective in slowing the progression of the virus in the body with only minimal side effects. The daily antiretroviral therapy (ART) uses a combination of HIV-1 medicines. A proportion of patients diagnosed with HIV-1, however, cannot take the ART for many...
For almost any conceivable protein, corresponding antibodies can be developed to block it from binding or changing shape, which ultimately prevents it from carrying out its normal function. As such, scientists have looked to antibodies as a way of shutting down proteins inside cells for decades, but there is still no consistent way to get...
Currently available flu vaccines are based on the rapidly changing viral hemagglutinin (HA) antigen, and are therefore quickly outdated. Thus new vaccines need to be developed each year. Now, a new study published in the journal Science on October 25, 2019, reports on a set of three novel antibodies that bind to another type of...
by Bob Yirka , Medical Xpress A team of researchers at Boston Children’s Hospital has learned more about the process of V(D)J recombination and how it makes use of chromatin looping to collect segments that are to be spliced. In their paper published in the journal Nature, the researchers outline their research and what they...
The findings could lead to a universal flu vaccine and more effective emergency treatments SCRIPPS RESEARCH INSTITUTE LA JOLLA, CA – A nationwide team of researchers has found an antibody that protects mice against a wide range of potentially lethal influenza viruses, advancing efforts to design of a universal vaccine that could either treat or...
UNIVERSITY OF YORK Concentrations of antibiotics found in some of the world’s rivers exceed ‘safe’ levels by up to 300 times, the first ever global study has discovered. Researchers looked for 14 commonly used antibiotics in rivers in 72 countries across six continents and found antibiotics at 65% of the sites monitored. Metronidazole, which is used to treat bacterial infections including skin...
by Atlas Antibodies Neural Stem Cells Collectively, markers against neural stem cells (NSCs) represent a robust tool in basic research and advanced regenerative medicine. Studies focused on differentiation toward specific neural lineages are supported by changes in the expression levels of specific markers, which can help to identify the presence of neural stem cells. Nestin and SOX2 are two commonly utilized markers for NSCs. Other markers expressed at the cellsurface are ABCG2, FGFR1 and Frizzled-9. NSCs differentiate into...
