by Rockefeller University Clonal bursting in germinal center as seen with Brainbow imaging. Credit: Laboratory of Lymphocyte Dynamics at The Rockefeller University Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check. But...
Tag: <span>B cell</span>
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Clinical trial: Off-the-shelf immunotherapy shows promise for B-cell lymphoma
by Julia Evangelou Strait, Washington University in St. Louis A phase 1 clinical trial co-led by researchers at WashU Medicine found that a new type of cell-based immunotherapy was safe for patients with several types of B-cell lymphoma, a type of blood cancer. Larger studies are needed to assess efficacy, but the approach shows promise. Pictured...
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Targeting type of B cell could reduce lupus disease, study suggests
by University of Pittsburgh Credit: Pixabay/CC0 Public Domain A group of University of Pittsburgh researchers has given new meaning to “knowing your ABCs.” In a new study, published in the Journal of Experimental Medicine, the team showed that a type of immune cell called age-associated B cells, or ABCs, are important drivers of lupus and that targeting these...
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When the body’s B cell training grounds stay open after hours
by Rockefeller University Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.11.031 If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its weapons-development facilities. Formed in response to infection and vaccination, these microscopic training grounds allow B cells to perfect the...
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Researchers use custom molecule to halt growth of multiple myeloma and diffuse large B cell lymphoma in mice
by Rockefeller University Press Compared with a control (left), treatment with a soluble BCMA decoy receptor (right) increases the number of dying cancer cells (brown) in a multiple myeloma tumor growing in mice. Credit: © 2022 Miao et al. Originally published in Journal of Experimental Medicine. 10.1084/jem.20220214 Researchers at Stanford University have developed “decoy receptor” molecules that...
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Epigenetic changes drive the fate of a B cell
by Massachusetts General Hospital 3D rendering of a B cell. Credit: Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. CC BY-SA 4.0 B cells are the immune cells responsible for creating antibodies, and most B cells, known as B2 cells, produce antibodies in response to a pathogen...