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FLIpping the switch: DNA regulator activates blood stem cells for improved transplantation success

by Weill Cornell Medical College Adult mobilized hematopoietic stem/progenitor cells (HSPCs) into which Fli-1 modified mRNA has been introduced are shown expanding on top of engineered vascular endothelial cells (ECs). The greyscale image has been colorized with ECs (large, spread, and spindle shaped) and HSPCs colored blue (small and roundish) and the boundaries for HSPCs emphasized...

Blood stem cell transplantation for an immune system reboot in MS patients
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Blood stem cell transplantation for an immune system reboot in MS patients

by  University of Zurich Credit: Pixabay/CC0 Public Domain Blood stem cell transplantation is a radical but highly effective therapy for multiple sclerosis. A study led by the University of Zurich has now examined in detail the way in which the treatment curbs the autoimmune disease and how the immune system regenerates afterwards. A better understanding of...

Bone marrow ‘map’ opens path to organoid-like blood stem cell production
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Bone marrow ‘map’ opens path to organoid-like blood stem cell production

by  Cincinnati Children’s Hospital Medical Center These maps pinpoint the location of blood progenitors and their differentiating offspring in the mouse bone marrow. This is the first study to image blood production at this level of detail, say experts at Cincinnati Children’s. Findings were published Feb 10, 2021, in Nature. Credit: Cincinnati Children’s Imagine a day when...