by Sanjukta Mondal , Medical Xpress Deep learning models trained on UK Biobank datasets for brain age estimation. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adr3757 In a new study reported in Science Advances, scientists analyzed MRI data stored at the UK Biobank and identified seven genes responsible for fast biological brain aging and 13 existing drugs that can target those genes....
Tag: <span>brain aging</span>
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Potbelly may be a sign of brain aging
Peer-Reviewed Publication Toho University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: This figure illustrates a putative relationship between adipose CX3CL1 and brain BDNF, and its age-related changes. In young mice, steroid hormones contribute to maintaining brain BDNF levels via adipose CX3CL1. However, in aged mice, a deficiency of adipose 11β-HSD1 leads to insensitivity to steroid hormones, which in turn decreases...
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Can We Stop Brain Aging? Scientists Uncover Mitochondrial Key
By American Association for the Advancement of ScienceJanuary 1, 20253 Comments3 Mins Read FacebookTwitterPinterestTelegram Share Researchers uncovered a mechanism called excitation-mitochondrial DNA transcription coupling (E-TCmito) linking neuronal activity to mitochondrial DNA transcription, crucial for maintaining brain function. Enhancing E-TCmito in aged mice improved cognition, offering a potential therapeutic target for age-related cognitive decline and neurodegenerative diseases....
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Key players in brain aging: New research identifies age-related damage on a cellular level
by Allen Institute for Brain Science Non-neuronal brain cells called tanycytes illuminated and color coded according to their depth in the hypothalamus brain of a mouse. They are one of the cell types in the mouse brain that show a large number of gene transcripts changing with age. Credit: Allen Institute Scientists at the Allen Institute...
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Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein
Posted Today Humans aren’t the only ones who grow forgetful as they age — fruit flies do, too. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that comes with aging. Brain – illustrative photo. Image credit: Pixabay (Free Pixabay license) A new study published...
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Trauma exposure accelerates brain aging which can lead to Alzheimer’s disease, study suggests
September 10, 2024 by The North American Menopause Society Credit: Human Brain ProjectAs the median age of our population rises, so does the number of people diagnosed with Alzheimer’s disease. With advances in technology, it’s easier to determine brain age and identify blood-based Alzheimer’s disease biomarkers. A new study links trauma exposure with brain age...
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Brain Aging Trajectories Identified in Post-Mortem Tissue
— Alzheimer’s may be driven by multicellular communities, analysis suggests by Judy George, Deputy Managing Editor, MedPage TodaySeptember 3, 2024 Key TakeawaysTwo distinct pathways of brain aging emerged in a cellular analysis of post-mortem brain tissue.One trajectory led to Alzheimer’s disease, the other to an alternative brain aging pathway.Cellular communities, not singular cell subpopulations, may...
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Gender variations in brain aging among Parkinson’s Disease patients
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLM In a recent study published in npj Parkinson’s Disease, researchers explored how sex influences brain aging in Parkinson’s disease (PD) by analyzing Magnetic Resonance Imaging (MRI)-derived brain age differences and their clinical correlations. Study: Differences in brain aging between sexes in Parkinson’s disease. Image Credit: SpeedKingz/Shutterstock.comStudy: Differences...
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Scientists identify how dietary restriction slows brain aging and increases lifespan
by Buck Institute for Research on Aging mtd interacts with the retromer complex and is required for retromer maintenance. Credit: Nature Communications (2024). DOI: 10.1038/s41467-023-44343-3Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck Institute...
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Long-term type 1 diabetes associated with accelerated brain aging
by Justin Jackson, Medical Xpress Machine Learning Indices, SPARE-AD and SPARE-BA, as a Function of Age. A, there was no significant difference observed between EDIC participants (blue) and controls without diabetes (orange). In panel B, EDIC participants showed a significant increase in predicted brain age (SPARE-BA) demonstrating more advanced brain aging patterns. SPARE-AD indicates spatial...
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