Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative stressPeer-Reviewed Publication Compuscript Ltd FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: C2C12 myotubes were treated with CMs of cachectic tumor cells or pro-cachectic inflammatory cytokines in the presence or absence of Z526 at various concentrations for 48 h. (A) The structural formula of Z526. (B) Z526’s effects on cell viability...
Tag: <span>Cachexia</span>
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Blocking FNDC5, the precursor of the exercise hormone irisin, protects mice from cancer-induced cachexia
by American Society for Bone and Mineral Research Credit: Pixabay/CC0 Public Domain The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found. When cancer patients develop cachexia, their...
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Cachexia: Symptoms, Treatment and Outlook
Cachexia is a condition that causes extreme weight loss as well as muscle wasting. The name comes from two Greek words: kakos, meaning “bad,” and hexis, meaning “condition.” The condition is a symptom or side effect of chronic conditions, such as cancer, type 1 diabetes, HIV, and multiple sclerosis. Older individuals with “failure to thrive” syndrome may also develop cachexia....