by Kelsey Geesler, Perelman School of Medicine at the University of Pennsylvania Summary of patients studied. Credit: Nature Medicine (2025). DOI: 10.1038/s41591-024-03478-6 Within a large group of more than 700 patients treated with CAR T cell therapy, researchers found no evidence that the therapy itself caused any type of secondary cancer in the modified T cells, according to...
Tag: <span>CAR T cell</span>
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Study identifies TBK1 as key to overcoming CAR T resistance
by Mass General Brigham Credit: Pixabay/CC0 Public Domain Russell W. Jenkins, MD, Ph.D., a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, “TBK1 is Identified as a...
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Small study adds to growing hope CAR-T cell therapy could revolutionize autoimmune disease treatment
By Theresa Gaffney ADOBEPeople with autoimmune disorders don’t usually get to talk about a cure. There’s symptom management, hopeful periods of remission often followed by relapses, but rarely a lasting fix for the way their immune system attacks healthy cells. If the immune system is an army, then those with conditions like lupus, multiple sclerosis, or...
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Disrupting a single gene could improve CAR T cell immunotherapy, new study shows
by Jim Stallard, Memorial Sloan Kettering Cancer Center Credit: Pixabay/CC0 Public Domain CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient’s T cells so they recognize and attack cancer cells. These CAR (chimeric antigen receptor) T...