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Discovery of C-reactive protein’s inflammatory pathway in diabetic kidneys offers new treatment avenues

by The University of Hong Kong Credit: Molecular Therapy (2024). DOI: 10.1016/j.ymthe.2024.11.018 A research team from the School of Chinese Medicine in the LKS Faculty of Medicine of the University of Hong Kong (HKUMed) has discovered that C-reactive protein (CRP) can exacerbate kidney inflammation caused by diabetes, also known as diabetic kidney disease (DKD), through a Smad3-NLRP3 inflammasome-dependent...

Regulatory protein offers a protective effect in the diabetic kidney
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Regulatory protein offers a protective effect in the diabetic kidney

by University of Tsukuba Credit: Marko Aliaksandr/Shutterstock The kidneys perform a critical role in the body by removing waste and excess fluid in the form of urine. In a condition known as diabetic nephropathy, complications from diabetes disrupt the ability of the kidneys to function properly. Now, researchers in Japan have shed new light on a potential...