by University of California – San Diego With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of “synthetic lethality,” exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells. Synthetic lethality results when non-lethal mutations in different genes become deadly when combined in...
by John Innes Centre Compounds tested for their potential as antibiotics have demonstrated promising activity against one of the deadliest infectious diseases—tuberculosis (TB). Researchers from the John Innes Centre evaluated two compounds with antibacterial properties, which had been produced by the company Redx Pharma as antibiotic candidates, particularly against TB. TB, which is caused by...
New optical sensing platform can detect genomic cancer biomarkers directly in patient tissues DUKE UNIVERSITY A CLOSE-UP VIEW OF A HANDFUL OF NANOSTARS USED TO CREATE A NEW TYPE OF CANCER DIAGNOSTIC. view more CREDIT: TUAN VO-DINH, DUKE UNIVERSITY Biomedical engineers at Duke University have engineered a method for simultaneously detecting the presence of multiple...
New data show how early episodes of hyperglycemia can have long-term effects CITY OF HOPE CITY OF HOPE’S RAMA NATARAJAN, PH.D., THE NATIONAL BUSINESS PRODUCTS INDUSTRY PROFESSOR IN DIABETES RESEARCH, view more CREDIT: CITY OF HOPE DUARTE, Calif. — For people with diabetes, vascular complications like kidney disease and atherosclerosis, which can lead to poor...
By NATALIE RAHHAL ACTING US HEALTH EDITOR University of California, San Diego, researchers found a cellular ‘master circuit’ that determines which of two ways yeast cells age in yeast By tweaking how proteins involved in the circuit interact, the scientists were able to create an entirely new pathway of aging for yeast cells Cells lived...
by Dana-Farber Cancer Institute When prostate cancer progresses to a more-dangerous metastatic state, it does so by resurrecting dormant molecular mechanisms that had guided the fetal development of the prostate gland but had been subsequently switched off, say scientists from Dana-Farber Cancer Institute. The study, an international collaboration with The Netherlands Cancer Institute, was published...
Researchers are scrambling to find other ways to diagnose the coronavirus and churn out millions of tests a week — a key step in returning to normality. The timing couldn’t have been worse. In March, just as Thailand’s coronavirus outbreak began to ramp up, three hospitals in Bangkok announced that they had suspended testing for...
For every cell in the body there comes a time when it must decide what it wants to do for the rest of its life. In an article published in the journal PNAS, National Institutes of Health researchers report for the first time that ancient viral genes that were once considered “junk DNA” may play...
Sequencing technologies are enabling a deeper analysis of the gut’s microbiome. Researchers can now explore what our microbial inhabitants are doing and how they contribute to, or protect from, disease. investigator of the Human Microbiome Bioactives Resource (HMBR), which provides platforms and methods to integrate 16S sequencing, shotgun metagenomics, metatranscriptomics and meta-metabolomics for microbiome discovery....
by Institute of Cancer Research Scientists have revealed details of the discovery of a new cancer drug that could be used to treat a range of cancer types, including some blood cancers and solid tumors. The drug, called fadraciclib, was jointly discovered by scientists at The Institute of Cancer Research, London, in collaboration with the...
