In their new study, the researchers show how a modified peptide, in mice, helps a cancer drug pass through the blood-brain barrier, which is known to be extremely difficult to penetrate and thus serves as a massive hindrance to treating brain tumors. “We were not only able to get a drug into the brain, but...
Tag: <span>glioblastoma</span>
Post
Making glioblastoma more vulnerable to treatment
by Medical College of Georgia at Augusta University Dr. Waaqo Daddacha. Credit: Michael Holahan, Augusta University In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment. Their target is SAMHD1, a protein which can protect us from viral infections by destroying an essential...
Post
Studies reveal new insights into gut microbiome impact on immunotherapy response in multiple cancers, including glioblastoma
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER ABSTRACTS: 2006, 2511 CHICAGO ― Two studies led by The University of Texas MD Anderson Cancer Center that shed new light on the potential of the gut microbiome as a targetable biomarker to improve responses to immunotherapy were presented today at the 2022 American Society for Clinical Oncology (ASCO) Annual Meeting. The findings include...
Post
Glioblastoma in older adults: Improving survival and quality of life
by Joe Dangor, Mayo Clinic Glioblastoma multiform – MRT T2 axial. Credit: Hellerhoff/Wikimedia Commons, CC BY-SA 3.0 Glioblastoma is an aggressive cancer that can occur in the brain or spinal cord. It can occur at any age, but glioblastoma is more common in older adults. The average age of diagnosis is 64. Also known as glioblastoma multiforme, glioblastoma...
Post
Major step forward in development of diagnostic blood test for
JANUARY 17, 2022 by University of Sussex Figure 1. Experimental pipeline. sEVs from GB patients and healthy volunteers’ blood samples were isolated through UC. The proteomic content of the sEVs were deciphered using mass spectrometry. Figure was created using BioRender.com. Credit: DOI: 10.3390/biomedicines10010125 Researchers at the University of Sussex are one step further to developing a...
Post
CBD reduces glioblastoma’s size, supportive environment in experimental model
by Medical College of Georgia at Augusta University Credit: CC0 Public Domain Inhaled CBD shrinks the size of the highly aggressive, lethal brain tumor glioblastoma in an animal model by reducing the essential support of its microenvironment, researchers report. “We saw a significant reduction in the size of the tumor and its microenvironment was different,”...
Post
Drug designed for Alzheimer’s disease may hold promise for treating glioblastoma
by Cleveland Clinic Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0 New Cleveland Clinic research has found that drugs originally designed to help treat Alzheimer’s disease may hold promise for glioblastoma, the most common and lethal type of primary brain tumor. The findings were published in Nature Cancer. A class of drugs called BACE1 inhibitors were once among...
Post
After Setbacks, Cell Therapy for Glioblastoma Moves onto New Chapter
Donald M. O’Rourke, MD, director of the Glioblastoma Translational Center of Excellence at Penn Medicine, feels energized. After a lot of frustration and too few successes, the cell therapy field has reached a new phase in its pursuit for better treatments for the deadly brain cancer glioblastoma multiforme (GBM). For decades, treatment approaches using surgery,...
Post
Antibody delivery technology empowers immunotherapy against glioblastoma and suppresses side effects
by Innovation Center of NanoMedicine Glucose-PEGylated avelumab prevented the growth of glioblastoma. Credit: 2021 Innovation Center of NanoMedicine Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering....
Post
Converting glioma cells into neurons may treat glioblastoma
by Cancer Biology and Medicine Credit: CC0 Public Domain Gliomas are the most common primary brain tumors in adults. Among them, the high-grade glioblastomas (GBMs) are particularly known to be notoriously aggressive and invasive, which makes it challenging to treat them. The disease rapidly progresses to an advanced stage in a short span of time,...